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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5609
Target Type SINGLE PROTEIN
Preferred Name Bcl-2 homologous antagonist/killer
Synonyms Apoptosis regulator BAK | BAK | BAK1 | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bcl-2 homologous antagonist/killer SINGLE PROTEIN Q16611

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137283 Bcl-xL/BAK PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000030110
Ensembl ENSG00000030110
GO Cellular Component GO:0005622 (intracellular)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031307 (integral component of mitochondrial outer membrane)
GO:0031966 (mitochondrial membrane)
GO:0046930 (pore complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0031072 (heat shock protein binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0051087 (chaperone binding)
GO:0051400 (BH domain binding)
GO Biological Process GO:0001776 (leukocyte homeostasis)
GO:0001782 (B cell homeostasis)
GO:0001783 (B cell apoptotic process)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0001974 (blood vessel remodeling)
GO:0002262 (myeloid cell homeostasis)
GO:0002352 (B cell negative selection)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007420 (brain development)
GO:0007568 (aging)
GO:0008053 (mitochondrial fusion)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0009620 (response to fungus)
GO:0010046 (response to mycotoxin)
GO:0010225 (response to UV-C)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0010332 (response to gamma radiation)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0010629 (negative regulation of gene expression)
GO:0014070 (response to organic cyclic compound)
GO:0019835 (cytolysis)
GO:0031018 (endocrine pancreas development)
GO:0031100 (organ regeneration)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0032471 (negative regulation of endoplasmic reticulum calcium ion concentration)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0034644 (cellular response to UV)
GO:0035108 (limb morphogenesis)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043496 (regulation of protein homodimerization activity)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0044346 (fibroblast apoptotic process)
GO:0045471 (response to ethanol)
GO:0045862 (positive regulation of proteolysis)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0048597 (post-embryonic camera-type eye morphogenesis)
GO:0048872 (homeostasis of number of cells)
GO:0051726 (regulation of cell cycle)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0060068 (vagina development)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070242 (thymocyte apoptotic process)
GO:0071260 (cellular response to mechanical stimulus)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097190 (apoptotic signaling pathway)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097202 (activation of cysteine-type endopeptidase activity)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)
GO:1902262 (apoptotic process involved in patterning of blood vessels)
GO:1903896 (positive regulation of IRE1-mediated unfolded protein response)
Wikipedia Bcl-2_homologous_antagonist_killer

Target Cross References - Protein

canSAR Q16611
Human Protein Atlas ENSG00000030110
IntAct Q16611
Open Targets ENSG00000030110
PharmGKB PA25253
Reactome R-HSA-111452 (Activation and oligomerization of BAK protein.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt C0H5Y7 Q16611 Q6I9T6 Q92533

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR026298 (Blc2_fam.)
IPR026308 (BAK.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2IMS 2IMT 2JBY 2JCN 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V 4UF1 5AJK 5FMI 5FMK
CREDO 2IMS 2IMT 2JBY 2JCN 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V 4UF1 5AJK 5FMI 5FMK
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