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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5609
Target Type SINGLE PROTEIN
Preferred Name Bcl-2 homologous antagonist/killer
Synonyms Apoptosis regulator BAK | BAK | BAK1 | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bcl-2 homologous antagonist/killer SINGLE PROTEIN Q16611

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000030110
Ensembl ENSG00000030110
GO Cellular Component GO:0031307 (integral to mitochondrial outer membrane)
GO:0046930 (pore complex)
GO Molecular Function GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001836 (release of cytochrome c from mitochondria)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0008629 (induction of apoptosis by intracellular signals)
GO:0008633 (activation of pro-apoptotic gene products)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0034644 (cellular response to UV)
GO:0043496 (regulation of protein homodimerization activity)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia Bcl-2_homologous_antagonist_killer

Target Cross References - Protein

canSAR Q16611
Human Protein Atlas ENSG00000030110
IntAct Q16611
PharmGKB PA25253
Reactome REACT_578 (Apoptosis.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt Q16611 Q6I9T6 Q92533

Target Cross References - Domain

InterPro IPR000712 (Bcl2_BH.)
IPR002475 (Bcl2-like_apoptosis.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2IMS 2IMT 2JBY 2JCN 2XPX 2YV6 3I1H 3QBR
CREDO 2IMS 2IMT 2JBY 2JCN 2XPX 2YV6 3I1H 3QBR
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