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Target Report Card

Target Name and Classification

Target ID CHEMBL5608
Preferred Name NT-3 growth factor receptor
Synonyms GP145-TrkC | NT-3 growth factor receptor | NTRK3 | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
NT-3 growth factor receptor SINGLE PROTEIN Q16288

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559684 Neurotrophic tyrosine kinase receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL603469 LESTAURTINIB NT-3 growth factor receptor inhibitor 3 PubMed
CHEMBL3545179 AZD-7451 NT-3 growth factor receptor inhibitor 1 PubMed PubMed
CHEMBL3545381 PLX-7486 NT-3 growth factor receptor inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140538
Ensembl ENSG00000140538
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005004 (GPI-linked ephrin receptor activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043121 (neurotrophin binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001764 (neuron migration)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007507 (heart development)
GO:0007623 (circadian rhythm)
GO:0008284 (positive regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019056 (modulation by virus of host transcription)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0032148 (activation of protein kinase B activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0038179 (neurotrophin signaling pathway)
GO:0042490 (mechanoreceptor differentiation)
GO:0043065 (positive regulation of apoptotic process)
GO:0045471 (response to ethanol)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048665 (neuron fate specification)
GO:0048678 (response to axon injury)
GO:0048691 (positive regulation of axon extension involved in regeneration)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051412 (response to corticosterone)
GO:0051965 (positive regulation of synapse assembly)
GO:0060548 (negative regulation of cell death)
GO:0070306 (lens fiber cell differentiation)
GO:0071300 (cellular response to retinoic acid)
GO:0090102 (cochlea development)
GO:0090630 (activation of GTPase activity)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
Wikipedia TrkC_receptor

Target Cross References - Protein

canSAR Q16288
Human Protein Atlas ENSG00000140538
IntAct Q16288
Guide to Pharmacology 1819
Open Targets ENSG00000140538
PharmGKB PA31819
Pharos Q16288 (Tchem)
UniProt B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16288 Q16289

Target Cross References - Domain

InterPro IPR000372 (LRRNT.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020446 (Tyr_kin_neurotrophic_rcpt_3.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020777 (Tyr_kinase_NGF_rcpt.)
IPR031635 (NTRK_C2.)
IPR032675 (L_dom-like.)
Pfam PF00047 (ig)
PF01462 (LRRNT)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)
PF13855 (LRR_8)
PF16920 (TPKR_C2)

Target Cross References - Structure