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Target Report Card

Target Name and Classification

Target ID CHEMBL5608
Target Type SINGLE PROTEIN
Preferred Name NT-3 growth factor receptor
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
NT-3 growth factor receptor SINGLE PROTEIN Q16288

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559684 Neurotrophic tyrosine kinase receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140538
Ensembl ENSG00000140538
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0043235 (receptor complex)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0002039 (p53 binding)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005524 (ATP binding)
GO:0043121 (neurotrophin binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007623 (circadian rhythm)
GO:0038179 (neurotrophin signaling pathway)
GO:0045471 (response to ethanol)
GO:0090102 (cochlea development)
GO:0046777 (protein autophosphorylation)
GO:0048665 (neuron fate specification)
GO:0060548 (negative regulation of cell death)
GO:0001764 (neuron migration)
GO:0010628 (positive regulation of gene expression)
GO:0030335 (positive regulation of cell migration)
GO:0048691 (positive regulation of axon extension involved in regeneration)
GO:0070306 (lens fiber cell differentiation)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
GO:0008284 (positive regulation of cell proliferation)
GO:0032148 (activation of protein kinase B activity)
GO:0042490 (mechanoreceptor differentiation)
GO:0071300 (cellular response to retinoic acid)
GO:0090630 (activation of GTPase activity)
GO:0007507 (heart development)
GO:0019056 (modulation by virus of host transcription)
GO:0043065 (positive regulation of apoptotic process)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:0051412 (response to corticosterone)
GO:0000187 (activation of MAPK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0048678 (response to axon injury)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051965 (positive regulation of synapse assembly)
Wikipedia TrkC_receptor

Target Cross References - Protein

canSAR Q16288
Human Protein Atlas ENSG00000140538
IntAct Q16288
Guide to Pharmacology 1819 (neurotrophic tyrosine kinase, receptor, type 3)
PharmGKB PA31819
UniProt O75682 Q16288 Q16289 Q12827

Target Cross References - Domain

InterPro IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR020446 (Tyr_kin_neurotrophic_rcpt_3.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR000719 (Prot_kinase_dom.)
IPR013098 (Ig_I-set.)
IPR000372 (LRRNT.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR013783 (Ig-like_fold.)
IPR020777 (Tyr_kinase_NGF_rcpt.)
IPR031635 (NTRK_C2.)
IPR011009 (Kinase-like_dom.)
IPR013151 (Immunoglobulin.)
Pfam PF00047 (ig)
PF01462 (LRRNT)
PF16920 (TPKR_C2)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)
PF13855 (LRR_8)

Target Cross References - Structure

PDBe 4YMJ 3V5Q 1WWC
CREDO 4YMJ 3V5Q 1WWC
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