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Target Report Card

Target Name and Classification

Target ID CHEMBL5606
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 11
Synonyms LKB1 | LKB1 | Liver kinase B1 | PJS | Renal carcinoma antigen NY-REN-19 | STK11 | Serine/threonine-protein kinase STK11 | hLKB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase lkb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase STK11 SINGLE PROTEIN Q15831

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118046
Ensembl ENSG00000118046
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0036398 (TCR signalosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030275 (LRR domain binding)
GO:0030295 (protein kinase activator activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0001894 (tissue homeostasis)
GO:0001944 (vasculature development)
GO:0006468 (protein phosphorylation)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007283 (spermatogenesis)
GO:0007286 (spermatid development)
GO:0007409 (axonogenesis)
GO:0008285 (negative regulation of cell proliferation)
GO:0010212 (response to ionizing radiation)
GO:0010508 (positive regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0030111 (regulation of Wnt signaling pathway)
GO:0030154 (cell differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0032147 (activation of protein kinase activity)
GO:0036399 (TCR signalosome assembly)
GO:0042593 (glucose homeostasis)
GO:0043276 (anoikis)
GO:0045059 (positive thymic T cell selection)
GO:0046777 (protein autophosphorylation)
GO:0048814 (regulation of dendrite morphogenesis)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050772 (positive regulation of axonogenesis)
GO:0050852 (T cell receptor signaling pathway)
GO:0051055 (negative regulation of lipid biosynthetic process)
GO:0051645 (Golgi localization)
GO:0051896 (regulation of protein kinase B signaling)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060770 (negative regulation of epithelial cell proliferation involved in prostate gland development)
GO:0071493 (cellular response to UV-B)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
GO:0097484 (dendrite extension)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904262 (negative regulation of TORC1 signaling)
Wikipedia STK11

Target Cross References - Protein

canSAR Q15831
CGD Peutz-Jeghers syndrome
Human Protein Atlas ENSG00000118046
IntAct Q15831
Guide to Pharmacology 2212
Open Targets ENSG00000118046
PharmGKB PA36198
Pharos Q15831 (Tchem)
Reactome R-HSA-163680 (AMPK inhibits chREBP transcriptional activation activity.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt B2RBX7 E7EW76 Q15831

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2WTK 4ZDR
CREDO 2WTK 4ZDR
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