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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5605
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Synonyms MAP3K7IP1 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 | TAB1 | TAK1-binding protein 1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | TGF-beta-activated kinase 1-binding protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 SINGLE PROTEIN Q15750

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038499 TAK1/TAB1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100324
Ensembl ENSG00000100324
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0010008 (endosome membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0008047 (enzyme activator activity)
GO:0019209 (kinase activator activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0000187 (activation of MAPK activity)
GO:0001701 (in utero embryonic development)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0003007 (heart morphogenesis)
GO:0003279 (cardiac septum development)
GO:0006470 (protein dephosphorylation)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007254 (JNK cascade)
GO:0030324 (lung development)
GO:0035904 (aorta development)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0060976 (coronary vasculature development)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
Wikipedia MAP3K7IP1

Target Cross References - Protein

canSAR Q15750
Human Protein Atlas ENSG00000100324
IntAct Q15750
Open Targets ENSG00000100324
PharmGKB PA30604
Pharos Q15750 (Tbio)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-937042 (IRAK2 mediated activation of TAK1 complex.)
R-HSA-937072 (TRAF6 mediated induction of TAK1 complex.)
R-HSA-975163 (IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.)
TIMBAL Tak1
UniProt Q15750 Q2PP09 Q8IZW2

Target Cross References - Domain

InterPro IPR001932 (PPM-type_phosphatase_dom.)
IPR015655 (PP2C.)
Pfam PF00481 (PP2C)

Target Cross References - Structure

PDBe 2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5JGA 5JGB 5JGD
CREDO 2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5JGA 5JGB 5JGD
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