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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5603
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor subfamily 0 group B member 2
Synonyms NR0B2 | Nuclear receptor subfamily 0 group B member 2 | Orphan nuclear receptor SHP | SHP | Small heterodimer partner
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 0 > nuclear hormone receptor subfamily 0 group b > nuclear hormone receptor subfamily 0 group b member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 0 group B member 2 SINGLE PROTEIN Q15466

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131910
Ensembl ENSG00000131910
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0043234 (protein complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003714 (transcription corepressor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019904 (protein domain specific binding)
GO:0032403 (protein complex binding)
GO:0042803 (protein homodimerization activity)
GO:0042974 (retinoic acid receptor binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0046965 (retinoid X receptor binding)
GO:0046966 (thyroid hormone receptor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007219 (Notch signaling pathway)
GO:0008203 (cholesterol metabolic process)
GO:0009749 (response to glucose)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0031100 (organ regeneration)
GO:0032024 (positive regulation of insulin secretion)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0045892 (negative regulation of transcription, DNA-templated)
Wikipedia Small_heterodimer_partner

Target Cross References - Protein

canSAR Q15466
Human Protein Atlas ENSG00000131910
IntAct Q15466
Guide to Pharmacology 636
Open Targets ENSG00000131910
PharmGKB PA31747
Pharos Q15466 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt F1D8P5 Q15466 Q5QP36

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001723 (Nuclear_hrmn_rcpt.)
Pfam PF00104 (Hormone_recep)

Target Cross References - Structure

PDBe 1YUC 2Q3Y 2Z4J 4DOR 4ONI
CREDO 1YUC 2Q3Y 2Z4J 4DOR 4ONI
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