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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5603
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor subfamily 0 group B member 2
Synonyms NR0B2 | Nuclear receptor subfamily 0 group B member 2 | Orphan nuclear receptor SHP | SHP | Small heterodimer partner
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 0 > nuclear hormone receptor subfamily 0 group b > nuclear hormone receptor subfamily 0 group b member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 0 group B member 2 SINGLE PROTEIN Q15466

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131910
Ensembl ENSG00000131910
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003714 (transcription corepressor activity)
GO:0019904 (protein domain specific binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0008203 (cholesterol metabolic process)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
Wikipedia Small_heterodimer_partner

Target Cross References - Protein

canSAR Q15466
Human Protein Atlas ENSG00000131910
Guide to Pharmacology 636 (NR0B2)
PharmGKB PA31747
Reactome REACT_71 (Gene Expression.)
UniProt Q15466 Q5QP36

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
Pfam PF00104 (Hormone_recep)

Target Cross References - Structure

PDBe 1YUC 2Q3Y 2Z4J
CREDO 1YUC 2Q3Y 2Z4J
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