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Target Report Card

Target Name and Classification

Target ID CHEMBL5602
Preferred Name Sonic hedgehog protein
Synonyms HHG-1 | SHH | SHH | Sonic hedgehog protein C-product | Sonic hedgehog protein N-product | Sonic hedgehog protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Sonic hedgehog protein SINGLE PROTEIN Q15465

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164690
Ensembl ENSG00000164690
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0005113 (patched binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005539 (glycosaminoglycan binding)
GO:0008233 (peptidase activity)
GO:0008270 (zinc ion binding)
GO:0016015 (morphogen activity)
GO:0016787 (hydrolase activity)
GO:0043237 (laminin-1 binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001525 (angiogenesis)
GO:0001569 (patterning of blood vessels)
GO:0001570 (vasculogenesis)
GO:0001656 (metanephros development)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001708 (cell fate specification)
GO:0001755 (neural crest cell migration)
GO:0001822 (kidney development)
GO:0001942 (hair follicle development)
GO:0001944 (vasculature development)
GO:0001947 (heart looping)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002076 (osteoblast development)
GO:0002320 (lymphoid progenitor cell differentiation)
GO:0003140 (determination of left/right asymmetry in lateral mesoderm)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006508 (proteolysis)
GO:0006897 (endocytosis)
GO:0007224 (smoothened signaling pathway)
GO:0007228 (positive regulation of hh target transcription factor activity)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0007368 (determination of left/right symmetry)
GO:0007389 (pattern specification process)
GO:0007398 (ectoderm development)
GO:0007405 (neuroblast proliferation)
GO:0007411 (axon guidance)
GO:0007417 (central nervous system development)
GO:0007418 (ventral midline development)
GO:0007442 (hindgut morphogenesis)
GO:0007507 (heart development)
GO:0007596 (blood coagulation)
GO:0008209 (androgen metabolic process)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009790 (embryo development)
GO:0009880 (embryonic pattern specification)
GO:0009949 (polarity specification of anterior/posterior axis)
GO:0009952 (anterior/posterior pattern specification)
GO:0009953 (dorsal/ventral pattern formation)
GO:0010463 (mesenchymal cell proliferation)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0014003 (oligodendrocyte development)
GO:0014706 (striated muscle tissue development)
GO:0014858 (positive regulation of skeletal muscle cell proliferation)
GO:0014902 (myotube differentiation)
GO:0016539 (intein-mediated protein splicing)
GO:0021513 (spinal cord dorsal/ventral patterning)
GO:0021522 (spinal cord motor neuron differentiation)
GO:0021794 (thalamus development)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0021930 (cerebellar granule cell precursor proliferation)
GO:0021938 (smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)
GO:0021940 (positive regulation of cerebellar granule cell precursor proliferation)
GO:0021978 (telencephalon regionalization)
GO:0030010 (establishment of cell polarity)
GO:0030162 (regulation of proteolysis)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0030323 (respiratory tube development)
GO:0030324 (lung development)
GO:0030326 (embryonic limb morphogenesis)
GO:0030336 (negative regulation of cell migration)
GO:0030539 (male genitalia development)
GO:0030850 (prostate gland development)
GO:0030878 (thyroid gland development)
GO:0030900 (forebrain development)
GO:0030901 (midbrain development)
GO:0030902 (hindbrain development)
GO:0031016 (pancreas development)
GO:0031069 (hair follicle morphogenesis)
GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0033077 (T cell differentiation in thymus)
GO:0033089 (positive regulation of T cell differentiation in thymus)
GO:0033092 (positive regulation of immature T cell proliferation in thymus)
GO:0034244 (negative regulation of transcription elongation from RNA polymerase II promoter)
GO:0034504 (protein localization to nucleus)
GO:0035115 (embryonic forelimb morphogenesis)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0042127 (regulation of cell proliferation)
GO:0042130 (negative regulation of T cell proliferation)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042476 (odontogenesis)
GO:0042481 (regulation of odontogenesis)
GO:0042733 (embryonic digit morphogenesis)
GO:0043010 (camera-type eye development)
GO:0043066 (negative regulation of apoptotic process)
GO:0043369 (CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)
GO:0043588 (skin development)
GO:0045059 (positive thymic T cell selection)
GO:0045060 (negative thymic T cell selection)
GO:0045109 (intermediate filament organization)
GO:0045165 (cell fate commitment)
GO:0045445 (myoblast differentiation)
GO:0045596 (negative regulation of cell differentiation)
GO:0045597 (positive regulation of cell differentiation)
GO:0045880 (positive regulation of smoothened signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0046639 (negative regulation of alpha-beta T cell differentiation)
GO:0048468 (cell development)
GO:0048538 (thymus development)
GO:0048546 (digestive tract morphogenesis)
GO:0048557 (embryonic digestive tract morphogenesis)
GO:0048568 (embryonic organ development)
GO:0048589 (developmental growth)
GO:0048598 (embryonic morphogenesis)
GO:0048617 (embryonic foregut morphogenesis)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0048645 (organ formation)
GO:0048646 (anatomical structure formation involved in morphogenesis)
GO:0048663 (neuron fate commitment)
GO:0048706 (embryonic skeletal system development)
GO:0048709 (oligodendrocyte differentiation)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048839 (inner ear development)
GO:0048856 (anatomical structure development)
GO:0048859 (formation of anatomical boundary)
GO:0048864 (stem cell development)
GO:0051146 (striated muscle cell differentiation)
GO:0051155 (positive regulation of striated muscle cell differentiation)
GO:0051781 (positive regulation of cell division)
GO:0060020 (Bergmann glial cell differentiation)
GO:0060021 (palate development)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060173 (limb development)
GO:0060174 (limb bud formation)
GO:0060425 (lung morphogenesis)
GO:0060428 (lung epithelium development)
GO:0060438 (trachea development)
GO:0060439 (trachea morphogenesis)
GO:0060441 (epithelial tube branching involved in lung morphogenesis)
GO:0060442 (branching involved in prostate gland morphogenesis)
GO:0060445 (branching involved in salivary gland morphogenesis)
GO:0060447 (bud outgrowth involved in lung branching)
GO:0060458 (right lung development)
GO:0060459 (left lung development)
GO:0060463 (lung lobe morphogenesis)
GO:0060484 (lung-associated mesenchyme development)
GO:0060516 (primary prostatic bud elongation)
GO:0060523 (prostate epithelial cord elongation)
GO:0060662 (salivary gland cavitation)
GO:0060664 (epithelial cell proliferation involved in salivary gland morphogenesis)
GO:0060684 (epithelial-mesenchymal cell signaling)
GO:0060685 (regulation of prostatic bud formation)
GO:0060738 (epithelial-mesenchymal signaling involved in prostate gland development)
GO:0060768 (regulation of epithelial cell proliferation involved in prostate gland development)
GO:0060769 (positive regulation of epithelial cell proliferation involved in prostate gland development)
GO:0060782 (regulation of mesenchymal cell proliferation involved in prostate gland development)
GO:0060783 (mesenchymal smoothened signaling pathway involved in prostate gland development)
GO:0060840 (artery development)
GO:0060916 (mesenchymal cell proliferation involved in lung development)
GO:0061053 (somite development)
GO:0061189 (positive regulation of sclerotome development)
GO:0071285 (cellular response to lithium ion)
GO:0071542 (dopaminergic neuron differentiation)
GO:0072001 (renal system development)
GO:0072136 (metanephric mesenchymal cell proliferation involved in metanephros development)
GO:0080125 (multicellular structure septum development)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090370 (negative regulation of cholesterol efflux)
GO:0097190 (apoptotic signaling pathway)
GO:1900175 (regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)
GO:1900180 (regulation of protein localization to nucleus)
GO:1904339 (negative regulation of dopaminergic neuron differentiation)
GO:2000062 (negative regulation of ureter smooth muscle cell differentiation)
GO:2000063 (positive regulation of ureter smooth muscle cell differentiation)
GO:2000357 (negative regulation of kidney smooth muscle cell differentiation)
GO:2000358 (positive regulation of kidney smooth muscle cell differentiation)
GO:2000729 (positive regulation of mesenchymal cell proliferation involved in ureter development)
GO:2001054 (negative regulation of mesenchymal cell apoptotic process)
Wikipedia Sonic_hedgehog

Target Cross References - Protein

canSAR Q15465
CGD Holoprosencephaly 3; Microphthalmia with coloboma 5
Human Protein Atlas ENSG00000164690
IntAct Q15465
Open Targets ENSG00000164690
PharmGKB PA35752
Reactome R-HSA-373080 (Class B/2 (Secretin family receptors).)
R-HSA-5358346 (Hedgehog ligand biogenesis.)
R-HSA-5362768 (Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.)
R-HSA-5362798 (Release of Hh-Np from the secreting cell.)
R-HSA-5632681 (Ligand-receptor interactions.)
R-HSA-5632684 (Hedgehog 'on' state.)
R-HSA-5635838 (Activation of SMO.)
R-HSA-5658034 (HHAT G278V abrogates palmitoylation of Hh-Np.)
UniProt A4D247 Q15465 Q75MC9

Target Cross References - Domain

InterPro IPR000320 (Hedgehog_signalling_dom.)
IPR001657 (Hedgehog.)
IPR001767 (Hint_dom.)
IPR003586 (Hint_dom_C.)
IPR003587 (Hint_dom_N.)
IPR006141 (Intein_N.)
IPR009045 (Hedgehog_sig/DD-Pept_Zn-bd_dom.)
IPR028992 (Hedgehog/Intein_dom.)
Pfam PF01079 (Hint)
PF01085 (HH_signal)

Target Cross References - Structure