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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5600
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase c-TAK1
Synonyms C-TAK1 | CTAK1 | Cdc25C-associated protein kinase 1 | ELKL motif kinase 2 | EMK-2 | EMK2 | MAP/microtubule affinity-regulating kinase 3 | MARK3 | Par-1a | Protein kinase STK10 | Ser/Thr protein kinase PAR-1 | Serine/threonine-protein kinase p78 | cTAK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase mark subfamily

Target Components

Component Description Relationship Accession
MAP/microtubule affinity-regulating kinase 3 SINGLE PROTEIN P27448

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075413
Ensembl ENSG00000075413
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
Wikipedia MARK3

Target Cross References - Protein

Human Protein Atlas ENSG00000075413
IntAct P27448
Guide to Pharmacology 2099
Open Targets ENSG00000075413
PharmGKB PA30640
Pharos P27448 (Tchem)
Reactome R-HSA-5673000 (RAF activation.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
UniProt O60219 P27448 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001772 (KA1_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015940 (UBA.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR033624 (MARK/par1.)
IPR033628 (MARK3.)
Pfam PF00069 (Pkinase)
PF00627 (UBA)
PF02149 (KA1)

Target Cross References - Structure

PDBe 2QNJ 3FE3
CREDO 2QNJ 3FE3
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