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Target Report Card

Target Name and Classification

Target ID CHEMBL5587
Preferred Name Cyclic AMP-responsive element-binding protein 1
Synonyms CREB-1 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | cAMP-responsive element-binding protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cyclic AMP-responsive element-binding protein 1 SINGLE PROTEIN P16220

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118260
Ensembl ENSG00000118260
GO Cellular Component GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005719 (nuclear euchromatin)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0030424 (axon)
GO:1990589 (ATF4-CREB1 transcription factor complex)
GO Molecular Function GO:0000975 (regulatory region DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001190 (transcriptional activator activity, RNA polymerase II transcription factor binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003712 (transcription cofactor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0030544 (Hsp70 protein binding)
GO:0035035 (histone acetyltransferase binding)
GO:0035497 (cAMP response element binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:1990763 (arrestin family protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007409 (axonogenesis)
GO:0007411 (axon guidance)
GO:0007568 (aging)
GO:0007595 (lactation)
GO:0007613 (memory)
GO:0007623 (circadian rhythm)
GO:0008361 (regulation of cell size)
GO:0008542 (visual learning)
GO:0010033 (response to organic substance)
GO:0010629 (negative regulation of gene expression)
GO:0010944 (negative regulation of transcription by competitive promoter binding)
GO:0014823 (response to activity)
GO:0016032 (viral process)
GO:0021983 (pituitary gland development)
GO:0030154 (cell differentiation)
GO:0030879 (mammary gland development)
GO:0032916 (positive regulation of transforming growth factor beta3 production)
GO:0033363 (secretory granule organization)
GO:0033762 (response to glucagon)
GO:0034670 (chemotaxis to arachidonic acid)
GO:0035094 (response to nicotine)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0036276 (response to antidepressant)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042493 (response to drug)
GO:0042752 (regulation of circadian rhythm)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045899 (positive regulation of RNA polymerase II transcriptional preinitiation complex assembly)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046887 (positive regulation of hormone secretion)
GO:0046889 (positive regulation of lipid biosynthetic process)
GO:0048145 (regulation of fibroblast proliferation)
GO:0048511 (rhythmic process)
GO:0050821 (protein stabilization)
GO:0060251 (regulation of glial cell proliferation)
GO:0060428 (lung epithelium development)
GO:0060430 (lung saccule development)
GO:0060509 (Type I pneumocyte differentiation)
GO:0071294 (cellular response to zinc ion)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071398 (cellular response to fatty acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901215 (negative regulation of neuron death)
GO:1902065 (response to L-glutamate)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:1990314 (cellular response to insulin-like growth factor stimulus)
Wikipedia CREB1

Target Cross References - Protein

canSAR P16220
Human Protein Atlas ENSG00000118260
IntAct P16220
Open Targets ENSG00000118260
PharmGKB PA26864
Reactome R-HSA-111931 (PKA-mediated phosphorylation of CREB.)
R-HSA-111932 (CaMK IV-mediated phosphorylation of CREB.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2197563 (NOTCH2 intracellular domain regulates transcription.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-400253 (Circadian Clock.)
R-HSA-442717 (CREB phosphorylation through the activation of CaMKK.)
R-HSA-442720 (CREB phosphorylation through the activation of Adenylate Cyclase.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
UniProt P16220 P21934 Q6V963 Q9UMA7

Target Cross References - Domain

InterPro IPR001630 (Leuzip_CREB.)
IPR003102 (Coactivator_CBP_pKID.)
IPR004827 (bZIP.)
Pfam PF00170 (bZIP_1)
PF02173 (pKID)