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Target Report Card

Target Name and Classification

Target ID CHEMBL5581
Preferred Name Ras-related C3 botulinum toxin substrate 2
Synonyms GX | RAC2 | Ras-related C3 botulinum toxin substrate 2 | Small G protein | p21-Rac2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ras-related C3 botulinum toxin substrate 2 SINGLE PROTEIN P15153

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128340
Ensembl ENSG00000128340
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030670 (phagocytic vesicle membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005525 (GTP binding)
GO:0019887 (protein kinase regulator activity)
GO Biological Process GO:0006935 (chemotaxis)
GO:0007015 (actin filament organization)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0010310 (regulation of hydrogen peroxide metabolic process)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010810 (regulation of cell-substrate adhesion)
GO:0030031 (cell projection assembly)
GO:0030036 (actin cytoskeleton organization)
GO:0030168 (platelet activation)
GO:0042129 (regulation of T cell proliferation)
GO:0043304 (regulation of mast cell degranulation)
GO:0045453 (bone resorption)
GO:0045859 (regulation of protein kinase activity)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0060263 (regulation of respiratory burst)
GO:0060753 (regulation of mast cell chemotaxis)
GO:0071593 (lymphocyte aggregation)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:1902622 (regulation of neutrophil migration)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
Wikipedia RAC2

Target Cross References - Protein

canSAR P15153
CGD Neutrophil immunodeficiency syndrome
Human Protein Atlas ENSG00000128340
IntAct P15153
Open Targets ENSG00000128340
PharmGKB PA34163
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-4086400 (PCP/CE pathway.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
UniProt P15153 Q9UDJ4

Target Cross References - Domain

InterPro IPR001806 (Small_GTPase.)
IPR005225 (Small_GTP-bd_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00071 (Ras)

Target Cross References - Structure

PDBe 1DS6 2W2T 2W2V 2W2X