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Target Report Card

Target Name and Classification

Target ID CHEMBL5573
Preferred Name Intestinal alkaline phosphatase
Synonyms ALPI | IAP | Intestinal alkaline phosphatase | Intestinal-type alkaline phosphatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Intestinal-type alkaline phosphatase SINGLE PROTEIN P09923

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163295
Ensembl ENSG00000163295
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031225 (anchored component of membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0002020 (protease binding)
GO:0003824 (catalytic activity)
GO:0004035 (alkaline phosphatase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006501 (C-terminal protein lipidation)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0007586 (digestion)
GO:0008152 (metabolic process)
GO:0016311 (dephosphorylation)
Wikipedia ALPI

Target Cross References - Protein

canSAR P09923
Human Protein Atlas ENSG00000163295
IntAct P09923
Open Targets ENSG00000163295
PharmGKB PA24728
Reactome R-HSA-1483166 (Synthesis of PA.)
R-HSA-163125 (Post-translational modification: synthesis of GPI-anchored proteins.)
R-HSA-8935690 (Digestion.)
UniProt B2R7Y4 P09923 Q53S80 Q9UBV5 Q9UCL2

Target Cross References - Domain

InterPro IPR001952 (Alkaline_phosphatase.)
IPR017849 (Alkaline_Pase-like_a/b/a.)
IPR017850 (Alkaline_phosphatase_core_sf.)
IPR018299 (Alkaline_phosphatase_AS.)
Pfam PF00245 (Alk_phosphatase)