ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5568
Target Type SINGLE PROTEIN
Preferred Name Proto-oncogene tyrosine-protein kinase ROS
Synonyms MCF3 | Proto-oncogene c-Ros | Proto-oncogene c-Ros-1 | Proto-oncogene tyrosine-protein kinase ROS | ROS | ROS1 | Receptor tyrosine kinase c-ros oncogene 1 | c-Ros receptor tyrosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase sev family

Target Components

Component Description Relationship Accession
Proto-oncogene tyrosine-protein kinase ROS SINGLE PROTEIN P08922

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000047936
Ensembl ENSG00000047936
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO Biological Process GO:0002066 (columnar/cuboidal epithelial cell development)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007283 (spermatogenesis)
GO:0008283 (cell proliferation)
GO:0010629 (negative regulation of gene expression)
GO:0010966 (regulation of phosphate transport)
GO:0016049 (cell growth)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030154 (cell differentiation)
GO:0032006 (regulation of TOR signaling)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
Wikipedia ROS1_(gene)

Target Cross References - Protein

canSAR P08922
Human Protein Atlas ENSG00000047936
IntAct P08922
Guide to Pharmacology 1840
Open Targets ENSG00000047936
PharmGKB PA34633
Pharos P08922 (Tchem)
UniProt P08922 Q15368 Q5TDB5

Target Cross References - Domain

InterPro IPR000033 (LDLR_classB_rpt.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00041 (fn3)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3ZBF 4UXL
CREDO 3ZBF 4UXL
spacer
spacer