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Target Report Card

Target Name and Classification

Target ID CHEMBL5554
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide
Synonyms C2-PI3K | PI3K-C2-beta | PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | Phosphoinositide 3-kinase-C2-beta | PtdIns-3-kinase C2 subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta SINGLE PROTEIN O00750

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133056
Ensembl ENSG00000133056
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0016020 (membrane)
GO:0030139 (endocytic vesicle)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001727 (lipid kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0035091 (phosphatidylinositol binding)
GO Biological Process GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0008150 (biological_process)
GO:0016310 (phosphorylation)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0043491 (protein kinase B signaling)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
Wikipedia PIK3C2B

Target Cross References - Protein

canSAR O00750
Human Protein Atlas ENSG00000133056
IntAct O00750
Guide to Pharmacology 2151
Open Targets ENSG00000133056
PharmGKB PA33305
Pharos O00750 (Tchem)
Reactome R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
UniProt O00750 O95666 Q5SW99

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR001683 (Phox.)
IPR002420 (PI3K_C2_dom.)
IPR011009 (Kinase-like_dom.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00168 (C2)
PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00787 (PX)
PF00792 (PI3K_C2)
PF00794 (PI3K_rbd)
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