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Target Report Card

Target Name and Classification

Target ID CHEMBL5551
Preferred Name Sodium/nucleoside cotransporter 1
Synonyms CNT 1 | CNT1 | Concentrative nucleoside transporter 1 | Na(+)/nucleoside cotransporter 1 | SLC28A1 | Sodium-coupled nucleoside transporter 1 | Sodium/nucleoside cotransporter 1 | Solute carrier family 28 member 1 | hCNT1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc28 and slc29 families of nucleoside transporters > slc28 na+-coupled nucleoside transport family

Target Components

Component Description Relationship Accession
Sodium/nucleoside cotransporter 1 SINGLE PROTEIN O00337

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156222
Ensembl ENSG00000156222
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0005337 (nucleoside transmembrane transporter activity)
GO:0005350 (pyrimidine nucleobase transmembrane transporter activity)
GO:0005415 (nucleoside:sodium symporter activity)
GO:0015389 (pyrimidine- and adenine-specific:sodium symporter activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006810 (transport)
GO:0006863 (purine nucleobase transport)
GO:0015855 (pyrimidine nucleobase transport)
GO:0015858 (nucleoside transport)
GO:0072531 (pyrimidine-containing compound transmembrane transport)
GO:1901642 (nucleoside transmembrane transport)
GO:1904823 (purine nucleobase transmembrane transport)
Wikipedia Concentrative_nucleoside_transporter_1

Target Cross References - Protein

canSAR O00337
Human Protein Atlas ENSG00000156222
Open Targets ENSG00000156222
PharmGKB PA387
Reactome R-HSA-83936 (Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.)
UniProt A0AV42 A8K7I2 O00335 O00336 O00337 Q5U5S6 Q5U648 Q9UEZ9

Target Cross References - Domain

InterPro IPR002668 (CNT_N_dom.)
IPR008276 (C_nuclsd_transpt.)
IPR011642 (Gate_dom.)
IPR011657 (CNT_C_dom.)
IPR018270 (C_nuclsd_transpt_met_bac.)
IPR030212 (CNT1/CNT2.)
Pfam PF01773 (Nucleos_tra2_N)
PF07662 (Nucleos_tra2_C)
PF07670 (Gate)