ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5542
Target Type SINGLE PROTEIN
Preferred Name DNA polymerase eta
Synonyms DNA polymerase eta | POLH | RAD30 | RAD30 homolog A | RAD30A | XPV | Xeroderma pigmentosum variant type protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA polymerase eta SINGLE PROTEIN Q9Y253

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170734
Ensembl ENSG00000170734
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003684 (damaged DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000731 (DNA synthesis involved in DNA repair)
GO:0006260 (DNA replication)
GO:0006282 (regulation of DNA repair)
GO:0010225 (response to UV-C)
Wikipedia POLH

Target Cross References - Protein

canSAR Q9Y253
CGD Xeroderma pigmentosum, variant type
Human Protein Atlas ENSG00000170734
IntAct Q9Y253
PharmGKB PA279
Reactome REACT_216 (DNA Repair.)
UniProt Q7L8E3 Q96BC4 Q9BX13 Q9Y253

Target Cross References - Domain

InterPro IPR001126 (DNA_repair_prot_UmuC-like.)
IPR017061 (DNA_pol_eta.)
IPR017961 (DNA_pol_Y-fam_little_finger.)
IPR017963 (DNA_repair_prot_UmuC-like_N.)
Pfam PF00817 (IMS)
PF11799 (IMS_C)

Target Cross References - Structure

PDBe 3MR2 3MR3 3MR4 3MR5 3MR6
CREDO 3MR2 3MR3 3MR4 3MR5 3MR6
spacer
spacer