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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5542
Target Type SINGLE PROTEIN
Preferred Name DNA polymerase eta
Synonyms DNA polymerase eta | POLH | RAD30 | RAD30 homolog A | RAD30A | XPV | Xeroderma pigmentosum variant type protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA polymerase eta SINGLE PROTEIN Q9Y253

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170734
Ensembl ENSG00000170734
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000731 (DNA synthesis involved in DNA repair)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006282 (regulation of DNA repair)
GO:0006290 (pyrimidine dimer repair)
GO:0006301 (postreplication repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0010225 (response to UV-C)
GO:0019985 (translesion synthesis)
GO:0070987 (error-free translesion synthesis)
GO:0071494 (cellular response to UV-C)
GO:0071897 (DNA biosynthetic process)
Wikipedia POLH

Target Cross References - Protein

canSAR Q9Y253
CGD Xeroderma pigmentosum, variant type
Human Protein Atlas ENSG00000170734
IntAct Q9Y253
Open Targets ENSG00000170734
PharmGKB PA279
Reactome R-HSA-110320 (Translesion Synthesis by POLH.)
R-HSA-5656169 (Termination of translesion DNA synthesis.)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
UniProt Q7L8E3 Q96BC4 Q9BX13 Q9Y253

Target Cross References - Domain

InterPro IPR001126 (UmuC.)
IPR017061 (DNA_pol_eta/kappa.)
IPR017961 (DNA_pol_Y-fam_little_finger.)
Pfam PF00817 (IMS)
PF11799 (IMS_C)

Target Cross References - Structure

PDBe 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 3WUP 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 More...
CREDO 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 3WUP 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 More...
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