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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5542
Preferred Name DNA polymerase eta
Synonyms DNA polymerase eta | POLH | RAD30 | RAD30 homolog A | RAD30A | XPV | Xeroderma pigmentosum variant type protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA polymerase eta SINGLE PROTEIN Q9Y253

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170734
Ensembl ENSG00000170734
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003684 (damaged DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000731 (DNA synthesis involved in DNA repair)
GO:0006260 (DNA replication)
GO:0006282 (regulation of DNA repair)
GO:0010225 (response to UV-C)
Wikipedia POLH

Target Cross References - Protein

canSAR Q9Y253
CGD Xeroderma pigmentosum, variant type
Human Protein Atlas ENSG00000170734
IntAct Q9Y253
PharmGKB PA279
Reactome REACT_216 (DNA Repair.)
UniProt Q7L8E3 Q96BC4 Q9BX13 Q9Y253

Target Cross References - Domain

InterPro IPR001126 (DNA_repair_prot_UmuC-like.)
IPR017061 (DNA_pol_eta.)
IPR017961 (DNA_pol_Y-fam_little_finger.)
IPR017963 (DNA_repair_prot_UmuC-like_N.)
Pfam PF00817 (IMS)
PF11799 (IMS_C)

Target Cross References - Structure

PDBe 3MR2 3MR3 3MR4 3MR5 3MR6
CREDO 3MR2 3MR3 3MR4 3MR5 3MR6