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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5533
Target Type SINGLE PROTEIN
Preferred Name Nuclear factor NF-kappa-B p65 subunit
Synonyms NFKB3 | Nuclear factor NF-kappa-B p65 subunit | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | RELA | Transcription factor p65
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor p65 SINGLE PROTEIN Q04206

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094258 Nuclear factor NF-kappa-B complex PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173039
Ensembl ENSG00000173039
GO Cellular Component GO:0005667 (transcription factor complex)
GO:0005829 (cytosol)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003705 (sequence-specific enhancer binding RNA polymerase II transcription factor activity)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO:0016564 (transcription repressor activity)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0033613 (activating transcription factor binding)
GO:0042301 (phosphate binding)
GO:0042802 (identical protein binding)
GO:0047485 (protein N-terminus binding)
GO:0051059 (NF-kappaB binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006916 (anti-apoptosis)
GO:0006954 (inflammatory response)
GO:0006968 (cellular defense response)
GO:0008063 (Toll signaling pathway)
GO:0010224 (response to UV-B)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0044419 (interspecies interaction between organisms)
GO:0045087 (innate immune response)
GO:0045892 (negative regulation of transcription, DNA-dependent)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050727 (regulation of inflammatory response)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051607 (defense response to virus)
GO:0070431 (nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0070555 (response to interleukin-1)
Wikipedia RELA

Target Cross References - Protein

canSAR Q04206
Human Protein Atlas ENSG00000173039
IntAct Q04206
PharmGKB PA296
Reactome REACT_11061 (Signalling by NGF.)
REACT_6900 (Signaling in Immune system.)
UniProt Q04206 Q6GTV1 Q6SLK1

Target Cross References - Domain

InterPro IPR000451 (NF_Rel_dor.)
IPR002909 (IPT_TIG_rcpt.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011539 (RHD.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
Pfam PF00554 (RHD)

Target Cross References - Structure

PDBe 1NFI 2O61 3GUT
CREDO 1NFI 2O61 3GUT
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