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Target Report Card

Target Name and Classification

Target ID CHEMBL5533
Preferred Name Nuclear factor NF-kappa-B p65 subunit
Synonyms NFKB3 | Nuclear factor NF-kappa-B p65 subunit | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | RELA | Transcription factor p65
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor p65 SINGLE PROTEIN Q04206

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094258 Nuclear factor NF-kappa-B complex PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173039
Ensembl ENSG00000173039
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO:0033256 (I-kappaB/NF-kappaB complex)
GO:0035525 (NF-kappaB p50/p65 complex)
GO:0071159 (NF-kappaB complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0000983 (transcription factor activity, RNA polymerase II core promoter sequence-specific)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001205 (transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0031490 (chromatin DNA binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0033613 (activating transcription factor binding)
GO:0042301 (phosphate ion binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0042805 (actinin binding)
GO:0042826 (histone deacetylase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044877 (macromolecular complex binding)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO:0051059 (NF-kappaB binding)
GO:0070491 (repressing transcription factor binding)
GO:0071532 (ankyrin repeat binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001889 (liver development)
GO:0001942 (hair follicle development)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006117 (acetaldehyde metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006968 (cellular defense response)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0009617 (response to bacterium)
GO:0009887 (organ morphogenesis)
GO:0010033 (response to organic substance)
GO:0010035 (response to inorganic substance)
GO:0010224 (response to UV-B)
GO:0014040 (positive regulation of Schwann cell differentiation)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0032332 (positive regulation of chondrocyte differentiation)
GO:0032481 (positive regulation of type I interferon production)
GO:0032495 (response to muramyl dipeptide)
GO:0032496 (response to lipopolysaccharide)
GO:0032570 (response to progesterone)
GO:0032868 (response to insulin)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0033234 (negative regulation of protein sumoylation)
GO:0033590 (response to cobalamin)
GO:0034097 (response to cytokine)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0035994 (response to muscle stretch)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043200 (response to amino acid)
GO:0043278 (response to morphine)
GO:0043620 (regulation of DNA-templated transcription in response to stress)
GO:0045084 (positive regulation of interleukin-12 biosynthetic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050727 (regulation of inflammatory response)
GO:0050852 (T cell receptor signaling pathway)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051591 (response to cAMP)
GO:0051607 (defense response to virus)
GO:0061614 (pri-miRNA transcription by RNA polymerase II)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070431 (nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071224 (cellular response to peptidoglycan)
GO:0071316 (cellular response to nicotine)
GO:0071347 (cellular response to interleukin-1)
GO:0071354 (cellular response to interleukin-6)
GO:0071356 (cellular response to tumor necrosis factor)
GO:1901222 (regulation of NIK/NF-kappaB signaling)
GO:1901223 (negative regulation of NIK/NF-kappaB signaling)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1901522 (positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1904385 (cellular response to angiotensin)
GO:2000630 (positive regulation of miRNA metabolic process)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia RELA

Target Cross References - Protein

canSAR Q04206
Human Protein Atlas ENSG00000173039
IntAct Q04206
Open Targets ENSG00000173039
PharmGKB PA296
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-3134963 (DEx/H-box helicases activate type I IFN and inflammatory cytokines production.)
R-HSA-3214841 (PKMTs methylate histone lysines.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-448706 (Interleukin-1 processing.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607761 (Dectin-1 mediated noncanonical NF-kB signaling.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5660668 (CLEC7A/inflammasome pathway.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
UniProt Q04206 Q6GTV1 Q6SLK1

Target Cross References - Domain

InterPro IPR000451 (NFkB/Dor.)
IPR002909 (IPT_dom.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011539 (RHD_DNA_bind_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR030492 (RHD_CS.)
IPR030495 (RelA.)
IPR032397 (RHD_dimer.)
IPR033926 (IPT_NFkappaB.)
IPR037059 (RHD_DNA_bind_dom_sf.)
Pfam PF00554 (RHD_DNA_bind)
PF16179 (RHD_dimer)

Target Cross References - Structure

PDBe 1NFI 2O61 3GUT 3QXY 3RC0 4KV1 4KV4