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Target Report Card

Target Name and Classification

Target ID CHEMBL5518
Preferred Name Misshapen-like kinase 1
Synonyms B55 | GCK family kinase MiNK | MAP4K6 | MAPK/ERK kinase kinase kinase 6 | MEK kinase kinase 6 | MEKKK 6 | MINK | MINK1 | Misshapen-like kinase 1 | Misshapen/NIK-related kinase | Mitogen-activated protein kinase kinase kinase kinase 6 | YSK2 | ZC3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase msn subfamily

Target Components

Component Description Relationship Accession
Misshapen-like kinase 1 SINGLE PROTEIN Q8N4C8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141503
Ensembl ENSG00000141503
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005083 (small GTPase regulator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
Wikipedia MINK1

Target Cross References - Protein

Human Protein Atlas ENSG00000141503
IntAct Q8N4C8
Guide to Pharmacology 2103 (misshapen-like kinase 1)
PharmGKB PA134910641
UniProt D3DTK3 D3DTK4 Q5U8Z0 Q8N4C8 Q9P1X1 Q9P2R8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001180 (Citron.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)