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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5514
Target Type SINGLE PROTEIN
Preferred Name Huntingtin
Synonyms HD | HD protein | HTT | Huntingtin | Huntington disease protein | IT15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Huntingtin SINGLE PROTEIN P42858

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197386
Ensembl ENSG00000197386
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005770 (late endosome)
GO:0005776 (autophagosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005814 (centriole)
GO:0005829 (cytosol)
GO:0014069 (postsynaptic density)
GO:0030136 (clathrin-coated vesicle)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO:0071598 (neuronal ribonucleoprotein granule)
GO Molecular Function GO:0002039 (p53 binding)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005522 (profilin binding)
GO:0008134 (transcription factor binding)
GO:0034452 (dynactin binding)
GO:0042802 (identical protein binding)
GO:0044325 (ion channel binding)
GO:0045505 (dynein intermediate chain binding)
GO:0048487 (beta-tubulin binding)
GO Biological Process GO:0000132 (establishment of mitotic spindle orientation)
GO:0006890 (retrograde vesicle-mediated transport, Golgi to ER)
GO:0006915 (apoptotic process)
GO:0007030 (Golgi organization)
GO:0007417 (central nervous system development)
GO:0031587 (positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
GO:0034047 (regulation of protein phosphatase type 2A activity)
GO:0042297 (vocal learning)
GO:0045724 (positive regulation of cilium assembly)
GO:0047496 (vesicle transport along microtubule)
GO:0048513 (animal organ development)
GO:0051028 (mRNA transport)
GO:2000117 (negative regulation of cysteine-type endopeptidase activity)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia Huntingtin

Target Cross References - Protein

CGD Huntington disease
Human Protein Atlas ENSG00000197386
IntAct P42858
Open Targets ENSG00000197386
PharmGKB PA164741646
UniProt P42858 Q9UQB7

Target Cross References - Domain

InterPro IPR000091 (Huntingtin.)
IPR011989 (ARM-like.)
IPR016024 (ARM-type_fold.)
IPR024613 (Huntingtin_middle-repeat.)
IPR028426 (Huntingtin_fam.)
Pfam PF12372 (DUF3652)

Target Cross References - Structure

PDBe 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV
CREDO 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV
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