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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5503
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor subfamily 1 group I member 3
Synonyms CAR | CAR | Constitutive activator of retinoid response | Constitutive active response | Constitutive androstane receptor | NR1I3 | Nuclear receptor subfamily 1 group I member 3 | Orphan nuclear receptor MB67
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group i > nuclear hormone receptor subfamily 1 group i member 3

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 1 group I member 3 SINGLE PROTEIN Q14994

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143257
Ensembl ENSG00000143257
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004882 (androgen receptor activity)
GO:0004887 (thyroid hormone receptor activity)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0030521 (androgen receptor signaling pathway)
GO:0030522 (intracellular receptor signaling pathway)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia Constitutive_androstane_receptor

Target Cross References - Protein

canSAR Q14994
Human Protein Atlas ENSG00000143257
IntAct Q14994
Guide to Pharmacology 607
Open Targets ENSG00000143257
PharmGKB PA391
Pharos Q14994 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt E9PB75 E9PC13 E9PDU3 E9PGH6 E9PH10 E9PHC8 E9PHN4 F1D8Q0 F1D8Q1 Q0VAC9 Q14994 Q4U0F0 Q5VTW5 Q5VTW6 Q6GZ68 Q6GZ76 Q6GZ77 Q6GZ78 Q6GZ79 Q6GZ82 Q6GZ83 Q6GZ84 Q6GZ85 Q6GZ87 Q6GZ89

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR001728 (ThyrH_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1XV9 1XVP
CREDO 1XV9 1XVP
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