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Target Report Card

Target Name and Classification

Target ID CHEMBL5500
Target Type SINGLE PROTEIN
Preferred Name Histone acetyltransferase PCAF
Synonyms Histone acetylase PCAF | Histone acetyltransferase KAT2B | Histone acetyltransferase PCAF | KAT2B | Lysine acetyltransferase 2B | P/CAF | P300/CBP-associated factor | PCAF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > gnat family
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
Histone acetyltransferase KAT2B SINGLE PROTEIN Q92831

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114166
Ensembl ENSG00000114166
GO Cellular Component GO:0000125 (PCAF complex)
GO:0000776 (kinetochore)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005671 (Ada2/Gcn5/Ada3 transcription activator complex)
GO:0005829 (cytosol)
GO:0016585 (chromatin remodeling complex)
GO:0031672 (A band)
GO:0031674 (I band)
GO:0042641 (actomyosin)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0003682 (chromatin binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0004468 (lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)
GO:0004861 (cyclin-dependent protein kinase inhibitor activity)
GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity)
GO:0008134 (transcription factor binding)
GO:0016407 (acetyltransferase activity)
GO:0019901 (protein kinase binding)
GO:0032403 (protein complex binding)
GO:0042826 (histone deacetylase binding)
GO Biological Process GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006360 (transcription from RNA polymerase I promoter)
GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0007050 (cell cycle arrest)
GO:0007219 (Notch signaling pathway)
GO:0007613 (memory)
GO:0008285 (negative regulation of cell proliferation)
GO:0010467 (gene expression)
GO:0010835 (regulation of protein ADP-ribosylation)
GO:0010976 (positive regulation of neuron projection development)
GO:0016032 (viral process)
GO:0018076 (N-terminal peptidyl-lysine acetylation)
GO:0018393 (internal peptidyl-lysine acetylation)
GO:0018394 (peptidyl-lysine acetylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0034599 (cellular response to oxidative stress)
GO:0035563 (positive regulation of chromatin binding)
GO:0035948 (positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter)
GO:0043966 (histone H3 acetylation)
GO:0043970 (histone H3-K9 acetylation)
GO:0044419 (interspecies interaction between organisms)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0071374 (cellular response to parathyroid hormone stimulus)
GO:0071442 (positive regulation of histone H3-K14 acetylation)
GO:2000617 (positive regulation of histone H3-K9 acetylation)
Wikipedia PCAF

Target Cross References - Protein

canSAR Q92831
Human Protein Atlas ENSG00000114166
IntAct Q92831
PharmGKB PA162392705
UniProt Q6NSK1 Q92831

Target Cross References - Domain

InterPro IPR000182 (AcTrfase_GCN5-related_dom.)
IPR000182 (GNAT_dom.)
IPR001487 (Bromodomain.)
IPR009464 (PCAF_N.)
IPR016181 (Acyl_CoA_acyltransferase.)
IPR016376 (Hist_acetylase_PCAF.)
IPR018359 (Bromodomain_CS.)
Pfam PF00439 (Bromodomain)
PF00583 (Acetyltransf_1)
PF06466 (PCAF_N)
PF13508 (Acetyltransf_7)

Target Cross References - Structure

PDBe 1CM0 3GG3 4NSQ
CREDO 1CM0 3GG3 4NSQ
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