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Target Report Card

Target Name and Classification

Target ID CHEMBL5500
Target Type SINGLE PROTEIN
Preferred Name Histone acetyltransferase PCAF
Synonyms Histone acetylase PCAF | Histone acetyltransferase KAT2B | Histone acetyltransferase PCAF | KAT2B | Lysine acetyltransferase 2B | P/CAF | P300/CBP-associated factor | PCAF | Synonyms=PCAF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > gnat family
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
Histone acetyltransferase KAT2B SINGLE PROTEIN Q92831

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885587 Histone acetyltransferase KAT2A/KAT2B PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114166
Ensembl ENSG00000114166
GO Cellular Component GO:0000123 (histone acetyltransferase complex)
GO:0000125 (PCAF complex)
GO:0000776 (kinetochore)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005671 (Ada2/Gcn5/Ada3 transcription activator complex)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO:0031672 (A band)
GO:0031674 (I band)
GO:0032991 (macromolecular complex)
GO:0042641 (actomyosin)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0003682 (chromatin binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0004468 (lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)
GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016407 (acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0019901 (protein kinase binding)
GO:0042826 (histone deacetylase binding)
GO:0044877 (macromolecular complex binding)
GO:0061733 (peptide-lysine-N-acetyltransferase activity)
GO Biological Process GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007219 (Notch signaling pathway)
GO:0007221 (positive regulation of transcription of Notch receptor target)
GO:0007507 (heart development)
GO:0008285 (negative regulation of cell proliferation)
GO:0010835 (regulation of protein ADP-ribosylation)
GO:0016032 (viral process)
GO:0016573 (histone acetylation)
GO:0016579 (protein deubiquitination)
GO:0018076 (N-terminal peptidyl-lysine acetylation)
GO:0018393 (internal peptidyl-lysine acetylation)
GO:0018394 (peptidyl-lysine acetylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0035948 (positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter)
GO:0043966 (histone H3 acetylation)
GO:0043970 (histone H3-K9 acetylation)
GO:0045652 (regulation of megakaryocyte differentiation)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0045815 (positive regulation of gene expression, epigenetic)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046600 (negative regulation of centriole replication)
GO:0048511 (rhythmic process)
GO:0060173 (limb development)
Wikipedia PCAF

Target Cross References - Protein

canSAR Q92831
Human Protein Atlas ENSG00000114166
IntAct Q92831
Guide to Pharmacology 2737
Open Targets ENSG00000114166
PharmGKB PA162392705
Reactome R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-350054 (Notch-HLH transcription pathway.)
R-HSA-5250924 (B-WICH complex positively regulates rRNA expression.)
R-HSA-5578768 (Physiological factors.)
R-HSA-5689901 (Metalloprotease DUBs.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-8936459 (RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.)
R-HSA-8941856 (RUNX3 regulates NOTCH signaling.)
R-HSA-9013508 (NOTCH3 Intracellular Domain Regulates Transcription.)
UniProt Q6NSK1 Q92831

Target Cross References - Domain

InterPro IPR000182 (GNAT_dom.)
IPR001487 (Bromodomain.)
IPR009464 (PCAF_N.)
IPR016181 (Acyl_CoA_acyltransferase.)
IPR016376 (GCN5/PCAF.)
IPR018359 (Bromodomain_CS.)
IPR036427 (Bromodomain-like_sf.)
Pfam PF00439 (Bromodomain)
PF00583 (Acetyltransf_1)
PF06466 (PCAF_N)

Target Cross References - Structure

PDBe 1CM0 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX
CREDO 1CM0 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX
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