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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5491
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase WEE1
Synonyms WEE1 | WEE1hu | Wee1-like protein kinase | Wee1A kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase wee family

Target Components

Component Description Relationship Accession
Wee1-like protein kinase SINGLE PROTEIN P30291

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166483
Ensembl ENSG00000166483
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0000075 (cell cycle checkpoint)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000084 (S phase of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007067 (mitosis)
GO:0007596 (blood coagulation)
GO:0051301 (cell division)
Wikipedia Wee1-like_protein_kinase

Target Cross References - Protein

canSAR P30291
Human Protein Atlas ENSG00000166483
IntAct P30291
Guide to Pharmacology 2278 (WEE1 G2 checkpoint kinase)
PharmGKB PA366
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_1538 (Cell Cycle Checkpoints.)
REACT_604 (Hemostasis.)
UniProt D3DQV0 P30291

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017164 (Wee1-like_protein_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
CREDO 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
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