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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5491
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase WEE1
Synonyms WEE1 | WEE1hu | Wee1-like protein kinase | Wee1A kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase wee family

Target Components

Component Description Relationship Accession
Wee1-like protein kinase SINGLE PROTEIN P30291

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1976040 AZD-1775 Serine/threonine-protein kinase WEE1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166483
Ensembl ENSG00000166483
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000226 (microtubule cytoskeleton organization)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0048812 (neuron projection morphogenesis)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
Wikipedia Wee1-like_protein_kinase

Target Cross References - Protein

canSAR P30291
Human Protein Atlas ENSG00000166483
IntAct P30291
Guide to Pharmacology 2278
Open Targets ENSG00000166483
PharmGKB PA366
Pharos P30291 (Tchem)
Reactome R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-69478 (G2/M DNA replication checkpoint.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B3KVE1 D3DQV0 P30291

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017164 (Wee1-like_protein_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
CREDO 1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
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