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Target Report Card

Target Name and Classification

Target ID CHEMBL5480
Preferred Name Perforin-1
Synonyms Cytolysin | Lymphocyte pore-forming protein | PFP | PFP | PRF1 | Perforin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > pore-forming toxins (proteins and peptides)

Target Components

Component Description Relationship Accession
Perforin-1 SINGLE PROTEIN P14222

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180644
Ensembl ENSG00000180644
GO Cellular Component GO:0005576 (extracellular region)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031904 (endosome lumen)
GO:0044194 (cytolytic granule)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0022829 (wide pore channel activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001771 (immunological synapse formation)
GO:0002357 (defense response to tumor cell)
GO:0002418 (immune response to tumor cell)
GO:0006915 (apoptotic process)
GO:0006968 (cellular defense response)
GO:0019835 (cytolysis)
GO:0051260 (protein homooligomerization)
GO:0051607 (defense response to virus)
GO:0051712 (positive regulation of killing of cells of other organism)
GO:0055085 (transmembrane transport)
Wikipedia Perforin

Target Cross References - Protein

canSAR P14222
CGD Hemophagocytic lymphohistiocytosis, familial, 2; Lymphoma, non-Hodgkin; Aplastic anemia, adult-onset
Human Protein Atlas ENSG00000180644
IntAct P14222
Open Targets ENSG00000180644
PharmGKB PA33732
UniProt B2R6X4 P14222 Q59F57 Q86WX7

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR020863 (MACPF_CS.)
IPR020864 (MACPF.)
IPR035892 (C2_domain_sf.)
IPR037300 (Perforin-1_C2.)
Pfam PF00168 (C2)
PF01823 (MACPF)