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Target Report Card

Target Name and Classification

Target ID CHEMBL5479
Preferred Name Hepatocyte growth factor
Synonyms HGF | HPTA | Hepatocyte growth factor alpha chain | Hepatocyte growth factor beta chain | Hepatocyte growth factor | Hepatopoietin-A | SF | Scatter factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Hepatocyte growth factor SINGLE PROTEIN P14210

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743063 RILOTUMUMAB Hepatocyte growth factor inhibitor 3 PubMed
CHEMBL1743018 FICLATUZUMAB Hepatocyte growth factor inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000019991
Ensembl ENSG00000019991
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0016020 (membrane)
GO:0031093 (platelet alpha granule lumen)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0042056 (chemoattractant activity)
GO:0042802 (identical protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0000902 (cell morphogenesis)
GO:0001837 (epithelial to mesenchymal transition)
GO:0001889 (liver development)
GO:0002576 (platelet degranulation)
GO:0006508 (proteolysis)
GO:0007067 (mitotic nuclear division)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010507 (negative regulation of autophagy)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0030212 (hyaluronan metabolic process)
GO:0030335 (positive regulation of cell migration)
GO:0031100 (organ regeneration)
GO:0031643 (positive regulation of myelination)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0050728 (negative regulation of inflammatory response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050918 (positive chemotaxis)
GO:0051450 (myoblast proliferation)
GO:0060326 (cell chemotaxis)
GO:0060665 (regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)
GO:0070572 (positive regulation of neuron projection regeneration)
GO:0090201 (negative regulation of release of cytochrome c from mitochondria)
GO:1900744 (regulation of p38MAPK cascade)
GO:1901299 (negative regulation of hydrogen peroxide-mediated programmed cell death)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902947 (regulation of tau-protein kinase activity)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia Hepatocyte_growth_factor

Target Cross References - Protein

canSAR P14210
CGD Deafness, autosomal recessive 39
Human Protein Atlas ENSG00000019991
IntAct P14210
Open Targets ENSG00000019991
PharmGKB PA29269
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1266695 (Interleukin-7 signaling.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6806942 (MET Receptor Activation.)
R-HSA-6807004 (Negative regulation of MET activity.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8851805 (MET activates RAS signaling.)
R-HSA-8851907 (MET activates PI3K/AKT signaling.)
R-HSA-8865999 (MET activates PTPN11.)
R-HSA-8874081 (MET activates PTK2 signaling.)
R-HSA-8875513 (MET interacts with TNS proteins.)
R-HSA-8875555 (MET activates RAP1 and RAC1.)
R-HSA-8875656 (MET receptor recycling.)
R-HSA-8875791 (MET activates STAT3.)
UniProt A1L3U6 P14210 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR003609 (Pan_app.)
IPR009003 (Peptidase_S1_PA.)
IPR013806 (Kringle-like.)
IPR018056 (Kringle_CS.)
IPR024174 (HGF-like.)
IPR027284 (Hepatocyte_GF.)
Pfam PF00024 (PAN_1)
PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ More...
CREDO 1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ More...