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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5479
Target Type SINGLE PROTEIN
Preferred Name Hepatocyte growth factor
Synonyms HGF | HPTA | Hepatocyte growth factor | Hepatocyte growth factor alpha chain | Hepatocyte growth factor beta chain | Hepatopoietin-A | SF | Scatter factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Hepatocyte growth factor SINGLE PROTEIN P14210

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000019991
Ensembl ENSG00000019991
GO Cellular Component GO:0031093 (platelet alpha granule lumen)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008083 (growth factor activity)
GO Biological Process GO:0001837 (epithelial to mesenchymal transition)
GO:0002576 (platelet degranulation)
GO:0006508 (proteolysis)
GO:0007067 (mitosis)
GO:0030168 (platelet activation)
GO:0060665 (regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)
Wikipedia Hepatocyte_growth_factor

Target Cross References - Protein

canSAR P14210
CGD Deafness, autosomal recessive 39
Human Protein Atlas ENSG00000019991
IntAct P14210
PharmGKB PA29269
Reactome REACT_604 (Hemostasis.)
UniProt A1L3U6 P14210 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR003014 (PAN-1_domain.)
IPR003609 (Pan_app.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR013806 (Kringle-like.)
IPR018056 (Kringle_CS.)
Pfam PF00024 (PAN_1)
PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2QJ2 3HMS 3HMT 3HN4 3MKP
CREDO 1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2QJ2 3HMS 3HMT 3HN4 3MKP
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