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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5477
Target Type SINGLE PROTEIN
Preferred Name Proteinase-activated receptor 3
Synonyms Coagulation factor II receptor-like 2 | F2RL2 | PAR-3 | PAR3 | Proteinase-activated receptor 3 | Thrombin receptor-like 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > protease-activated receptor > protease-activated receptor

Target Components

Component Description Relationship Accession
Proteinase-activated receptor 3 SINGLE PROTEIN O00254

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164220
Ensembl ENSG00000164220
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0015057 (thrombin receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0009611 (response to wounding)
GO:0030168 (platelet activation)
GO:0070493 (thrombin receptor signaling pathway)
Wikipedia F2RL2

Target Cross References - Protein

canSAR O00254
Human Protein Atlas ENSG00000164220
IntAct O00254
Open Targets ENSG00000164220
PharmGKB PA27948
Pharos O00254 (Tbio)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
UniProt B2R754 B4DQ13 O00254 Q52M68 Q7Z3W3

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003912 (Protea_act_rcpt.)
IPR003943 (Prot_act_rcpt_3.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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