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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5476
Target Type SINGLE PROTEIN
Preferred Name Bone morphogenetic protein receptor type-1B
Synonyms BMP type-1B receptor | BMPR-1B | BMPR1B | Bone morphogenetic protein receptor type-1B | CD_antigen=CDw293
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
Bone morphogenetic protein receptor type-1B SINGLE PROTEIN O00238

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138696
Ensembl ENSG00000138696
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043235 (receptor complex)
GO:1990712 (HFE-transferrin receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005025 (transforming growth factor beta receptor activity, type I)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001502 (cartilage condensation)
GO:0001550 (ovarian cumulus expansion)
GO:0001654 (eye development)
GO:0002062 (chondrocyte differentiation)
GO:0002063 (chondrocyte development)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0009953 (dorsal/ventral pattern formation)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030154 (cell differentiation)
GO:0030166 (proteoglycan biosynthetic process)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0032332 (positive regulation of chondrocyte differentiation)
GO:0035108 (limb morphogenesis)
GO:0042698 (ovulation cycle)
GO:0043010 (camera-type eye development)
GO:0045597 (positive regulation of cell differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051216 (cartilage development)
GO:0060041 (retina development in camera-type eye)
GO:0060350 (endochondral bone morphogenesis)
GO:0061036 (positive regulation of cartilage development)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071773 (cellular response to BMP stimulus)
GO:1902043 (positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902731 (negative regulation of chondrocyte proliferation)
Wikipedia BMPR1B

Target Cross References - Protein

canSAR O00238
CGD Chondrodysplasia, acromesomelic, with genital anomalies; Brachydactyly A2; Brachydactyly C/Symphalangism-like phenotype
Human Protein Atlas ENSG00000138696
IntAct O00238
Guide to Pharmacology 1789
Open Targets ENSG00000138696
PharmGKB PA25387
Pharos O00238 (Tbio)
Reactome R-HSA-201451 (Signaling by BMP.)
UniProt B2R953 B4DSV1 O00238 P78366

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000472 (Activin_recp.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF01064 (Activin_recp)
PF07714 (Pkinase_Tyr)
PF08515 (TGF_beta_GS)

Target Cross References - Structure

PDBe 3MDY
CREDO 3MDY
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