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Target Report Card

Target Name and Classification

Target ID CHEMBL5469
Target Type SINGLE PROTEIN
Preferred Name Protein tyrosine kinase 2 beta
Synonyms CADTK | CAK-beta | CAKB | Calcium-dependent tyrosine kinase | Calcium-regulated non-receptor proline-rich tyrosine kinase | Cell adhesion kinase beta | FADK 2 | FAK2 | Focal adhesion kinase 2 | PTK2B | PYK2 | Proline-rich tyrosine kinase 2 | Protein-tyrosine kinase 2-beta | RAFTK | RAFTK | Related adhesion focal tyrosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fak family

Target Components

Component Description Relationship Accession
Protein-tyrosine kinase 2-beta SINGLE PROTEIN Q14289

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3137331 DEFACTINIB Protein tyrosine kinase 2 beta inhibitor 2 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120899
Ensembl ENSG00000120899
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0044297 (cell body)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097440 (apical dendrite)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032403 (protein complex binding)
GO:0043423 (3-phosphoinositide-dependent protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000302 (response to reactive oxygen species)
GO:0001525 (angiogenesis)
GO:0001556 (oocyte maturation)
GO:0001666 (response to hypoxia)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002040 (sprouting angiogenesis)
GO:0002250 (adaptive immune response)
GO:0002315 (marginal zone B cell differentiation)
GO:0002376 (immune system process)
GO:0002688 (regulation of leukocyte chemotaxis)
GO:0006461 (protein complex assembly)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006950 (response to stress)
GO:0006968 (cellular defense response)
GO:0006970 (response to osmotic stress)
GO:0007015 (actin filament organization)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007172 (signal complex assembly)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009612 (response to mechanical stimulus)
GO:0009725 (response to hormone)
GO:0009749 (response to glucose)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0010752 (regulation of cGMP-mediated signaling)
GO:0010758 (regulation of macrophage chemotaxis)
GO:0010976 (positive regulation of neuron projection development)
GO:0014009 (glial cell proliferation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030155 (regulation of cell adhesion)
GO:0030279 (negative regulation of ossification)
GO:0030307 (positive regulation of cell growth)
GO:0030334 (regulation of cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0030500 (regulation of bone mineralization)
GO:0030502 (negative regulation of bone mineralization)
GO:0030826 (regulation of cGMP biosynthetic process)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031175 (neuron projection development)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032960 (regulation of inositol trisphosphate biosynthetic process)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035902 (response to immobilization stress)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042976 (activation of Janus kinase activity)
GO:0043066 (negative regulation of apoptotic process)
GO:0043149 (stress fiber assembly)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043534 (blood vessel endothelial cell migration)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045428 (regulation of nitric oxide biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045453 (bone resorption)
GO:0045471 (response to ethanol)
GO:0045638 (negative regulation of myeloid cell differentiation)
GO:0045727 (positive regulation of translation)
GO:0045765 (regulation of angiogenesis)
GO:0045766 (positive regulation of angiogenesis)
GO:0045860 (positive regulation of protein kinase activity)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048041 (focal adhesion assembly)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050848 (regulation of calcium-mediated signaling)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051279 (regulation of release of sequestered calcium ion into cytosol)
GO:0051591 (response to cAMP)
GO:0051592 (response to calcium ion)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071300 (cellular response to retinoic acid)
GO:0071498 (cellular response to fluid shear stress)
GO:0090630 (activation of GTPase activity)
GO:2000058 (regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2000060 (positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2000114 (regulation of establishment of cell polarity)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2000538 (positive regulation of B cell chemotaxis)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia PTK2B

Target Cross References - Protein

canSAR Q14289
Human Protein Atlas ENSG00000120899
IntAct Q14289
Guide to Pharmacology 2181
Open Targets ENSG00000120899
PharmGKB PA33956
Pharos Q14289 (Tchem)
Reactome R-HSA-391160 (Signal regulatory protein (SIRP) family interactions.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-451927 (Interleukin-2 signaling.)
UniProt D3DST0 Q13475 Q14289 Q14290 Q16709 Q6PID4

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR005189 (Focal_adhesion_kin_target_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR014352 (FERM/acyl-CoA-bd_prot_3-hlx.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR029071 (Ubiquitin-rel_dom.)
IPR030610 (PTK2B.)
Pfam PF00373 (FERM_M)
PF03623 (Focal_AT)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8
CREDO 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8
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