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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5469
Target Type SINGLE PROTEIN
Preferred Name Protein tyrosine kinase 2 beta
Synonyms CADTK | CAK-beta | CAKB | Calcium-dependent tyrosine kinase | Calcium-regulated non-receptor proline-rich tyrosine kinase | Cell adhesion kinase beta | FADK 2 | FAK2 | Focal adhesion kinase 2 | PTK2B | PYK2 | Proline-rich tyrosine kinase 2 | Protein-tyrosine kinase 2-beta | RAFTK | RAFTK | Related adhesion focal tyrosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fak family

Target Components

Component Description Relationship Accession
Protein-tyrosine kinase 2-beta SINGLE PROTEIN Q14289

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120899
Ensembl ENSG00000120899
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006915 (apoptosis)
GO:0007172 (signal complex assembly)
GO:0008284 (positive regulation of cell proliferation)
GO:0045453 (bone resorption)
Wikipedia PTK2B

Target Cross References - Protein

canSAR Q14289
Human Protein Atlas ENSG00000120899
IntAct Q14289
Guide to Pharmacology 2181 (protein tyrosine kinase 2 beta)
PharmGKB PA33956
Reactome REACT_20676 (Cell junction organization.)
REACT_23853 (Interactions of the immunoglobulin superfamily (IgSF) member proteins.)
REACT_6900 (Signaling in Immune system.)
UniProt D3DST0 Q13475 Q14289 Q14290 Q16709

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR005189 (Focal_adhesion_kin_target_dom.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014352 (FERM/acyl-CoA-bd_prot_3-hlx.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00373 (FERM_M)
PF03623 (Focal_AT)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C
CREDO 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C
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