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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5465
Target Type SINGLE PROTEIN
Preferred Name Polycystin-2
Synonyms Autosomal dominant polycystic kidney disease type II protein | PKD2 | Polycystic kidney disease 2 protein | Polycystin-2 | Polycystwin | R48321
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Polycystin-2 SINGLE PROTEIN Q13563

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118762
Ensembl ENSG00000118762
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005932 (microtubule basal body)
GO:0009925 (basal plasma membrane)
GO:0016021 (integral to membrane)
GO:0030027 (lamellipodium)
GO:0045180 (basal cortex)
GO Molecular Function GO:0005247 (voltage-gated chloride channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005509 (calcium ion binding)
GO:0008092 (cytoskeletal protein binding)
Wikipedia Polycystic_kidney_disease_2

Target Cross References - Protein

canSAR Q13563
CGD Polycystic kidney disease 2
Human Protein Atlas ENSG00000118762
Guide to Pharmacology 504 (TRPP1)
PharmGKB PA33343
UniProt O60441 Q13563 Q15764 Q2M1Q3 Q2M1Q5

Target Cross References - Domain

InterPro IPR003915 (PKD_2.)
IPR011992 (EF-hand-like_dom.)
IPR013122 (PKD1_2_channel.)
IPR018249 (EF_HAND_2.)
Pfam PF08016 (PKD_channel)

Target Cross References - Structure

PDBe 3HRN 3HRO
CREDO 3HRN 3HRO
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