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Target Report Card

Target Name and Classification

Target ID CHEMBL5464
Target Type SINGLE PROTEIN
Preferred Name Receptor-interacting serine/threonine-protein kinase 1
Synonyms Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Serine/threonine-protein kinase RIP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase ripk family

Target Components

Component Description Relationship Accession
Receptor-interacting serine/threonine-protein kinase 1 SINGLE PROTEIN Q13546

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137275
Ensembl ENSG00000137275
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031264 (death-inducing signaling complex)
GO:0043234 (protein complex)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO:0097342 (ripoptosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005123 (death receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032403 (protein complex binding)
GO:0042802 (identical protein binding)
GO:0070513 (death domain binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007257 (activation of JUN kinase activity)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010939 (regulation of necrotic cell death)
GO:0010940 (positive regulation of necrotic cell death)
GO:0010942 (positive regulation of cell death)
GO:0012501 (programmed cell death)
GO:0016310 (phosphorylation)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034612 (response to tumor necrosis factor)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0036289 (peptidyl-serine autophosphorylation)
GO:0042327 (positive regulation of phosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043068 (positive regulation of programmed cell death)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043410 (positive regulation of MAPK cascade)
GO:0044257 (cellular protein catabolic process)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051260 (protein homooligomerization)
GO:0051291 (protein heterooligomerization)
GO:0060545 (positive regulation of necroptotic process)
GO:0070231 (T cell apoptotic process)
GO:0070266 (necroptotic process)
GO:0070926 (regulation of ATP:ADP antiporter activity)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071550 (death-inducing signaling complex assembly)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:0097343 (ripoptosome assembly)
GO:0097527 (necroptotic signaling pathway)
GO:1901026 (ripoptosome assembly involved in necroptotic process)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1905206 (positive regulation of hydrogen peroxide-induced cell death)
GO:1990000 (amyloid fibril formation)
GO:2000377 (regulation of reactive oxygen species metabolic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia RIPK1

Target Cross References - Protein

canSAR Q13546
Human Protein Atlas ENSG00000137275
IntAct Q13546
Guide to Pharmacology 2189
Open Targets ENSG00000137275
PharmGKB PA34394
Pharos Q13546 (Tchem)
Reactome R-HSA-140534 (Ligand-dependent caspase activation.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-2562578 (TRIF-mediated programmed cell death.)
R-HSA-3295583 (TRP channels.)
R-HSA-3371378 (Regulation by c-FLIP.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5218900 (CASP8 activity is inhibited.)
R-HSA-5357786 (TNFR1-induced proapoptotic signaling.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5675482 (Regulation of necroptotic cell death.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-5689896 (Ovarian tumor domain proteases.)
R-HSA-69416 (Dimerization of procaspase-8.)
R-HSA-75893 (TNF signaling.)
R-HSA-933543 (NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10.)
R-HSA-937041 (IKK complex recruitment mediated by RIP1.)
UniProt A0AV89 B2RAG1 B4E3F9 Q13180 Q13546 Q59H33

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011029 (DEATH-like_dom.)
IPR025735 (RHIM_dom.)
Pfam PF00531 (Death)
PF07714 (Pkinase_Tyr)
PF12721 (RHIM)

Target Cross References - Structure

PDBe 4ITH 4ITI 4ITJ 4NEU 5HX6
CREDO 4ITH 4ITI 4ITJ 4NEU 5HX6
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