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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5463
Target Type SINGLE PROTEIN
Preferred Name Acid ceramidase
Synonyms AC | ACDase | ASAH | ASAH1 | Acid CDase | Acid ceramidase subunit alpha | Acid ceramidase subunit beta | Acid ceramidase | Acylsphingosine deacylase | HSD33 | N-acylsphingosine amidohydrolase | PHP32 | Putative 32 kDa heart protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acid ceramidase SINGLE PROTEIN Q13510

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104763
Ensembl ENSG00000104763
GO Cellular Component GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0016787 (hydrolase activity)
GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
GO:0017040 (ceramidase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006672 (ceramide metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
Wikipedia ASAH1

Target Cross References - Protein

canSAR Q13510
CGD Farber lipogranulomatosis
Human Protein Atlas ENSG00000104763
IntAct Q13510
Open Targets ENSG00000104763
PharmGKB PA35025
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt E9PDS0 Q13510 Q6W898 Q96AS2

Target Cross References - Domain

InterPro IPR003199 (Chologlycine_hydro/PeptC59.)
IPR016699 (Acid_ceramidase-like.)
IPR029130 (Acid_ceramidase_N.)
IPR029132 (CBAH/NAAA_C.)
Pfam PF02275 (CBAH)
PF15508 (NAAA-beta)
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