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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5461
Target Type SINGLE PROTEIN
Preferred Name Zinc finger protein GLI1
Synonyms GLI | GLI1 | Glioma-associated oncogene | Oncogene GLI | Zinc finger protein GLI1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Zinc finger protein GLI1 SINGLE PROTEIN P08151

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111087
Ensembl ENSG00000111087
GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO Molecular Function GO:0003677 (DNA binding)
GO:0008270 (zinc ion binding)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0009913 (epidermal cell differentiation)
GO:0045740 (positive regulation of DNA replication)
GO:0045880 (positive regulation of smoothened signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0090090 (negative regulation of canonical Wnt receptor signaling pathway)
Wikipedia GLI1

Target Cross References - Protein

canSAR P08151
Human Protein Atlas ENSG00000111087
IntAct P08151
PharmGKB PA28720
UniProt P08151 Q8TDN9

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)

Target Cross References - Structure

PDBe 2GLI
CREDO 2GLI
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