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Target Report Card

Target Name and Classification

Target ID CHEMBL5461
Target Type SINGLE PROTEIN
Preferred Name Zinc finger protein GLI1
Synonyms GLI | GLI1 | Glioma-associated oncogene | Oncogene GLI | Zinc finger protein GLI1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Zinc finger protein GLI1 SINGLE PROTEIN P08151

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111087
Ensembl ENSG00000111087
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005929 (cilium)
GO:0005930 (axoneme)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0072372 (primary cilium)
GO:0097542 (ciliary tip)
GO:0097546 (ciliary base)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007224 (smoothened signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007283 (spermatogenesis)
GO:0007418 (ventral midline development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0009611 (response to wounding)
GO:0009913 (epidermal cell differentiation)
GO:0009953 (dorsal/ventral pattern formation)
GO:0009954 (proximal/distal pattern formation)
GO:0021696 (cerebellar cortex morphogenesis)
GO:0021938 (smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)
GO:0021983 (pituitary gland development)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030335 (positive regulation of cell migration)
GO:0045667 (regulation of osteoblast differentiation)
GO:0045740 (positive regulation of DNA replication)
GO:0045880 (positive regulation of smoothened signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048546 (digestive tract morphogenesis)
GO:0060032 (notochord regression)
GO:0060070 (canonical Wnt signaling pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097421 (liver regeneration)
GO:2000345 (regulation of hepatocyte proliferation)
Wikipedia GLI1

Target Cross References - Protein

canSAR P08151
Human Protein Atlas ENSG00000111087
IntAct P08151
Open Targets ENSG00000111087
PharmGKB PA28720
Reactome R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5632684 (Hedgehog 'on' state.)
R-HSA-5635851 (GLI proteins bind promoters of Hh responsive genes to promote transcription.)
UniProt D0EUY3 E9PQQ9 F5H6H8 P08151 Q8TDN9

Target Cross References - Domain

InterPro IPR007087 (Znf_C2H2.)
IPR013087 (Znf_C2H2/integrase_DNA-bd.)
IPR015880 (Znf_C2H2-like.)
IPR032850 (GLI1.)

Target Cross References - Structure

PDBe 2GLI 4BLB 4KMD
CREDO 2GLI 4BLB 4KMD
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