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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5455
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase FES
Synonyms FES | FPS | Feline sarcoma/Fujinami avian sarcoma oncogene homolog | Proto-oncogene c-Fes | Proto-oncogene c-Fps | Tyrosine-protein kinase Fes/Fps | p93c-fes
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fer family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fes/Fps SINGLE PROTEIN P07332

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182511
Ensembl ENSG00000182511
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0015630 (microtubule cytoskeleton)
GO:0016023 (cytoplasmic membrane-bounded vesicle)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0034987 (immunoglobulin receptor binding)
GO:0035091 (phosphatidylinositol binding)
GO Biological Process GO:0001578 (microtubule bundle formation)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organismal development)
GO:0007411 (axon guidance)
GO:0008283 (cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0010976 (positive regulation of neuron projection development)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030155 (regulation of cell adhesion)
GO:0031116 (positive regulation of microtubule polymerization)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0043304 (regulation of mast cell degranulation)
GO:0045087 (innate immune response)
GO:0045595 (regulation of cell differentiation)
GO:0045639 (positive regulation of myeloid cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0051297 (centrosome organization)
GO:0060627 (regulation of vesicle-mediated transport)
GO:2000145 (regulation of cell motility)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
Wikipedia Feline_sarcoma_oncogene

Target Cross References - Protein

canSAR P07332
Human Protein Atlas ENSG00000182511
IntAct P07332
PharmGKB PA28098
UniProt B2R6E6 B4DUD0 E9PC94 E9PC95 P07332 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001060 (FCH.)
IPR001060 (FCH_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016250 (Tyr-prot_kinase_Fes/Fps.)
IPR016250 (Tyr_kinase_non-rcpt_Fes_subgr.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR031160 (F_BAR.)
Pfam PF00017 (SH2)
PF00611 (FCH)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3BKB 3CBL 3CD3 4DYL 4E93
CREDO 3BKB 3CBL 3CD3 4DYL 4E93
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