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Target Report Card

Target Name and Classification

Target ID CHEMBL5451
Preferred Name Sodium channel protein type X alpha subunit
Synonyms PN3 | Peripheral nerve sodium channel 3 | SCN10A | Sodium channel protein type 10 subunit alpha | Sodium channel protein type X subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.8 | hPN3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 10 subunit alpha SINGLE PROTEIN Q9Y5Y9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200612 DIBUCAINE HYDROCHLORIDE Sodium channel protein type X alpha subunit blocker 4 PubMed PubMed
CHEMBL3544951 PF-04531083 Sodium channel protein type X alpha subunit blocker 2 Other PubMed
CHEMBL3545165 AFACIFENACIN Sodium channel protein type X alpha subunit blocker 2 Other Other PubMed
CHEMBL3545012 DSP-2230 Sodium channel protein type X alpha subunit blocker 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185313
Ensembl ENSG00000185313
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO:0071439 (clathrin complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0044325 (ion channel binding)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0007600 (sensory perception)
GO:0019228 (neuronal action potential)
GO:0019233 (sensory perception of pain)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0055085 (transmembrane transport)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060371 (regulation of atrial cardiac muscle cell membrane depolarization)
GO:0086010 (membrane depolarization during action potential)
GO:0086016 (AV node cell action potential)
GO:0086043 (bundle of His cell action potential)
Wikipedia SCN10A

Target Cross References - Protein

canSAR Q9Y5Y9
Human Protein Atlas ENSG00000185313
Guide to Pharmacology 585
Open Targets ENSG00000185313
PharmGKB PA35000
Pharos Q9Y5Y9 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt A6NDQ1 Q9Y5Y9

Target Cross References - Domain

InterPro IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR027359 (Volt_channel_dom_sf.)
IPR028809 (Na_channel_a10su.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)