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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5433
Target Type SINGLE PROTEIN
Preferred Name Tryptophan 5-hydroxylase 2
Synonyms NTPH | Neuronal tryptophan hydroxylase | TPH2 | Tryptophan 5-hydroxylase 2 | Tryptophan 5-monooxygenase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tryptophan 5-hydroxylase 2 SINGLE PROTEIN Q8IWU9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831287 Tryptophan 5-hydroxylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139287
Ensembl ENSG00000139287
GO Cellular Component GO:0005829 (cytosol)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004510 (tryptophan 5-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016597 (amino acid binding)
GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007623 (circadian rhythm)
GO:0008152 (metabolic process)
GO:0009072 (aromatic amino acid family metabolic process)
GO:0014823 (response to activity)
GO:0031667 (response to nutrient levels)
GO:0042427 (serotonin biosynthetic process)
GO:0043627 (response to estrogen)
GO:0046219 (indolalkylamine biosynthetic process)
GO:0051384 (response to glucocorticoid)
GO:0051592 (response to calcium ion)
GO:0055114 (oxidation-reduction process)
GO:0071285 (cellular response to lithium ion)
Wikipedia TPH2

Target Cross References - Protein

canSAR Q8IWU9
Human Protein Atlas ENSG00000139287
IntAct Q8IWU9
Open Targets ENSG00000139287
PharmGKB PA128747823
Reactome R-HSA-209931 (Serotonin and melatonin biosynthesis.)
UniProt A6NGA4 Q14CB0 Q8IWU9

Target Cross References - Domain

InterPro IPR001273 (ArAA_hydroxylase.)
IPR002912 (ACT_dom.)
IPR005963 (Trp_5_mOase.)
IPR018301 (ArAA_hydroxylase_Fe/CU_BS.)
IPR019773 (Tyrosine_3-monooxygenase-like.)
IPR019774 (Aromatic-AA_hydroxylase_C.)
Pfam PF00351 (Biopterin_H)

Target Cross References - Structure

PDBe 4V06
CREDO 4V06
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