ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5401
Target Type SINGLE PROTEIN
Preferred Name Signal transducer and activator of transcription 6
Synonyms IL-4 Stat | STAT6 | Signal transducer and activator of transcription 6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 6 SINGLE PROTEIN P42226

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166888
Ensembl ENSG00000166888
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031965 (nuclear membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0019903 (protein phosphatase binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0002296 (T-helper 1 cell lineage commitment)
GO:0002829 (negative regulation of type 2 immune response)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032481 (positive regulation of type I interferon production)
GO:0033598 (mammary gland epithelial cell proliferation)
GO:0034097 (response to cytokine)
GO:0035771 (interleukin-4-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048295 (positive regulation of isotype switching to IgE isotypes)
GO:0060443 (mammary gland morphogenesis)
GO:0070301 (cellular response to hydrogen peroxide)
GO:1902170 (cellular response to reactive nitrogen species)
Wikipedia STAT6

Target Cross References - Protein

canSAR P42226
Human Protein Atlas ENSG00000166888
IntAct P42226
Open Targets ENSG00000166888
PharmGKB PA339
Reactome R-HSA-186763 (Downstream signal transduction.)
R-HSA-3249367 (STAT6-mediated induction of chemokines.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A8K316 B7ZA27 F5GXI9 P42226 Q5FBW5 Q71UP4

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR012345 (STAT_TF_DNA-bd_N.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
IPR028187 (STAT6_C.)
IPR035857 (STAT6_SH2.)
IPR036535 (STAT_N_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)
PF14596 (STAT6_C)

Target Cross References - Structure

PDBe 1OJ5 4Y5U 4Y5W 5D39 5NWX
CREDO 1OJ5 4Y5U 4Y5W 5D39 5NWX
spacer
spacer