ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5399
Preferred Name Pituitary adenylate cyclase-activating polypeptide type I receptor
Synonyms ADCYAP1R1 | PACAP type I receptor | PACAP-R-1 | PACAP-R1 | Pituitary adenylate cyclase-activating polypeptide type I receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Pituitary adenylate cyclase-activating polypeptide type I receptor SINGLE PROTEIN P41586

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078549
Ensembl ENSG00000078549
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005791 (rough endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0005923 (bicellular tight junction)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004999 (vasoactive intestinal polypeptide receptor activity)
GO:0005515 (protein binding)
GO:0008179 (adenylate cyclase binding)
GO:0030306 (ADP-ribosylation factor binding)
GO:0038023 (signaling receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007275 (multicellular organism development)
GO:0007283 (spermatogenesis)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0019933 (cAMP-mediated signaling)
GO:0030154 (cell differentiation)
GO:0032355 (response to estradiol)
GO:0033555 (multicellular organismal response to stress)
GO:0042493 (response to drug)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045471 (response to ethanol)
GO:0046545 (development of primary female sexual characteristics)
GO:0051057 (positive regulation of small GTPase mediated signal transduction)
GO:0060548 (negative regulation of cell death)
GO:0060732 (positive regulation of inositol phosphate biosynthetic process)
Wikipedia ADCYAP1R1

Target Cross References - Protein

canSAR P41586
Human Protein Atlas ENSG00000078549
IntAct P41586
Guide to Pharmacology 370
Open Targets ENSG00000078549
PharmGKB PA24565
Pharos P41586 (Tchem)
Reactome R-HSA-187024 (NGF-independant TRKA activation.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
UniProt A8K1Y1 B7ZLA7 B8ZZK3 P41586 Q17S10

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR002285 (GPCR_2_PACAP_1_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
IPR036445 (GPCR_2_extracell_dom_sf.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 3N94