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Target Report Card

Target Name and Classification

Target ID CHEMBL5398
Preferred Name Hepatocyte nuclear factor 4-alpha
Synonyms HNF-4-alpha | HNF4 | HNF4A | Hepatocyte nuclear factor 4-alpha | NR2A1 | Nuclear receptor subfamily 2 group A member 1 | TCF-14 | TCF14 | Transcription factor 14 | Transcription factor HNF-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Hepatocyte nuclear factor 4-alpha SINGLE PROTEIN P41235

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL253371 ALVERINE Hepatocyte nuclear factor 4-alpha activator 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101076
Ensembl ENSG00000101076
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005102 (receptor binding)
GO:0005504 (fatty acid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006591 (ornithine metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007548 (sex differentiation)
GO:0007596 (blood coagulation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009749 (response to glucose)
GO:0010470 (regulation of gastrulation)
GO:0019216 (regulation of lipid metabolic process)
GO:0023019 (signal transduction involved in regulation of gene expression)
GO:0030308 (negative regulation of cell growth)
GO:0030522 (intracellular receptor signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0042632 (cholesterol homeostasis)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050796 (regulation of insulin secretion)
GO:0055088 (lipid homeostasis)
GO:0055091 (phospholipid homeostasis)
GO:0060395 (SMAD protein signal transduction)
GO:0060398 (regulation of growth hormone receptor signaling pathway)
GO:0070328 (triglyceride homeostasis)
Wikipedia Hepatocyte_nuclear_factor_4_alpha

Target Cross References - Protein

canSAR P41235
CGD Congenital hyperinsulinism, diazoxide-responsive; Maturity onset diabetes of the young, 1
Human Protein Atlas ENSG00000101076
IntAct P41235
Open Targets ENSG00000101076
PharmGKB PA29349
Pharos P41235 (Tbio)
Reactome R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A5JW41 B2RPP8 O00659 O00723 P41235 Q14540 Q5QPB8 Q6B4V5 Q6B4V6 Q6B4V7 Q92653 Q92654 Q92655 Q99864 Q9NQH0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003068 (COUP_TF.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure