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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5378
Target Type SINGLE PROTEIN
Preferred Name P-selectin
Synonyms CD62 antigen-like family member P | CD_antigen=CD62P | GMP-140 | GMRP | GRMP | Granule membrane protein 140 | LECAM3 | Leukocyte-endothelial cell adhesion molecule 3 | P-selectin | PADGEM | Platelet activation dependent granule-external membrane protein | SELP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
P-selectin SINGLE PROTEIN P16109

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301394 P-selectin/P-selectin glycoprotein ligand 1 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000174175
Ensembl ENSG00000174175
GO Cellular Component GO:0005615 (extracellular space)
GO:0005624 (membrane fraction)
GO:0005625 (soluble fraction)
GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0031088 (platelet dense granule membrane)
GO:0031092 (platelet alpha granule membrane)
GO Molecular Function GO:0001530 (lipopolysaccharide binding)
GO:0008201 (heparin binding)
GO:0033691 (sialic acid binding)
GO:0042806 (fucose binding)
GO:0043208 (glycosphingolipid binding)
GO:0070492 (oligosaccharide binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0010572 (positive regulation of platelet activation)
GO:0030168 (platelet activation)
Wikipedia P-selectin

Target Cross References - Protein

canSAR P16109
Human Protein Atlas ENSG00000174175
PharmGKB PA35643
Reactome REACT_604 (Hemostasis.)
UniProt P16109 Q5R344 Q8IVD1

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP.)
IPR000742 (EGF_3.)
IPR001304 (C-type_lectin.)
IPR002396 (Selectin_superfamily.)
IPR006210 (EGF-like.)
IPR013032 (EGF-like_reg_CS.)
IPR016060 (Complement_control_module.)
IPR016186 (C-type_lectin-like.)
IPR016187 (C-type_lectin_fold.)
IPR018378 (C-type_lectin_CS.)
Pfam PF00059 (Lectin_C)
PF00084 (Sushi)

Target Cross References - Structure

PDBe 1G1Q 1G1R 1G1S 1HES
CREDO 1G1Q 1G1R 1G1S 1HES
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