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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5378
Target Type SINGLE PROTEIN
Preferred Name P-selectin
Synonyms CD62 antigen-like family member P | CD_antigen=CD62P | GMP-140 | GMRP | GRMP | Granule membrane protein 140 | LECAM3 | Leukocyte-endothelial cell adhesion molecule 3 | P-selectin | PADGEM | Platelet activation dependent granule-external membrane protein | SELP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
P-selectin SINGLE PROTEIN P16109

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831288 Selectin PROTEIN FAMILY
CHEMBL3301394 P-selectin/P-selectin glycoprotein ligand 1 PROTEIN-PROTEIN INTERACTION

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3707446 RIVIPANSEL P-selectin antagonist 3 PubMed
CHEMBL2109487 RG-1512 P-selectin inhibitor 2 PubMed
CHEMBL2109650 RO-4905417 P-selectin inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174175
Ensembl ENSG00000174175
GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031088 (platelet dense granule membrane)
GO:0031092 (platelet alpha granule membrane)
GO Molecular Function GO:0001530 (lipopolysaccharide binding)
GO:0001948 (glycoprotein binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0030246 (carbohydrate binding)
GO:0033691 (sialic acid binding)
GO:0042806 (fucose binding)
GO:0043208 (glycosphingolipid binding)
GO:0048306 (calcium-dependent protein binding)
GO:0070492 (oligosaccharide binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0002691 (regulation of cellular extravasation)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0010572 (positive regulation of platelet activation)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0014070 (response to organic cyclic compound)
GO:0016337 (single organismal cell-cell adhesion)
GO:0032496 (response to lipopolysaccharide)
GO:0033623 (regulation of integrin activation)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0045785 (positive regulation of cell adhesion)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
Wikipedia P-selectin

Target Cross References - Protein

canSAR P16109
Human Protein Atlas ENSG00000174175
IntAct P16109
Open Targets ENSG00000174175
PharmGKB PA35643
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
UniProt P16109 Q5R344 Q8IVD1

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP_dom.)
IPR000742 (EGF-like_dom.)
IPR001304 (C-type_lectin-like.)
IPR002396 (Selectin_superfamily.)
IPR013032 (EGF-like_CS.)
IPR016186 (C-type_lectin-like/link.)
IPR016187 (CTDL_fold.)
IPR018378 (C-type_lectin_CS.)
IPR033991 (Selectin_CTLD.)
Pfam PF00059 (Lectin_C)
PF00084 (Sushi)

Target Cross References - Structure

PDBe 1G1Q 1G1R 1G1S 1HES
CREDO 1G1Q 1G1R 1G1S 1HES
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