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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5366
Target Type SINGLE PROTEIN
Preferred Name Poly [ADP-ribose] polymerase 2
Synonyms ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ADPRT2 | ADPRTL2 | ARTD2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2 | Poly [ADP-ribose] polymerase 2 | Poly[ADP-ribose] synthase 2 | hPARP-2 | pADPRT-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Poly [ADP-ribose] polymerase 2 SINGLE PROTEIN Q9UGN5

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3390820 PARP 1, 2 and 3 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1094636 NIRAPARIB Poly [ADP-ribose] polymerase 2 inhibitor 4 PubMed
CHEMBL3137320 TALAZOPARIB Poly [ADP-ribose] polymerase 2 inhibitor 3 PubMed
CHEMBL3137318 TALAZOPARIB TOSYLATE Poly [ADP-ribose] polymerase 2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129484
Ensembl ENSG00000129484
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003910 (DNA ligase (ATP) activity)
GO:0003950 (NAD+ ADP-ribosyltransferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:1990404 (protein ADP-ribosylase activity)
GO Biological Process GO:0006273 (lagging strand elongation)
GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006471 (protein ADP-ribosylation)
GO:0018312 (peptidyl-serine ADP-ribosylation)
GO:0051103 (DNA ligation involved in DNA repair)
GO:0097191 (extrinsic apoptotic signaling pathway)
Wikipedia PARP2

Target Cross References - Protein

canSAR Q9UGN5
Human Protein Atlas ENSG00000129484
IntAct Q9UGN5
Guide to Pharmacology 2772
Open Targets ENSG00000129484
PharmGKB PA24592
Reactome R-HSA-110362 (POLB-Dependent Long Patch Base Excision Repair.)
R-HSA-5685939 (HDR through MMEJ (alt-NHEJ).)
R-HSA-5696394 (DNA Damage Recognition in GG-NER.)
R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-5696400 (Dual Incision in GG-NER.)
UniProt Q8TEU4 Q9NUV2 Q9UGN5 Q9UMR4 Q9Y6C8

Target Cross References - Domain

InterPro IPR004102 (Poly(ADP-ribose)pol_reg_dom.)
IPR008893 (WGR_domain.)
IPR012317 (Poly(ADP-ribose)pol_cat_dom.)
IPR036616 (Poly(ADP-ribose)pol_reg_dom_sf.)
IPR036930 (WGR_dom_sf.)
Pfam PF00644 (PARP)
PF02877 (PARP_reg)
PF05406 (WGR)

Target Cross References - Structure

PDBe 3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY
CREDO 3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY
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