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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5364
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine protein kinase NLK
Synonyms LAK1 | NLK | Nemo-like kinase | Protein LAK1 | Serine/threonine-protein kinase NLK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase nmo subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase NLK SINGLE PROTEIN Q9UBE8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087095
Ensembl ENSG00000087095
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042169 (SH2 domain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0010468 (regulation of gene expression)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0035556 (intracellular signal transduction)
GO:0042501 (serine phosphorylation of STAT protein)
GO:0046777 (protein autophosphorylation)
GO:0050821 (protein stabilization)
Wikipedia NLK

Target Cross References - Protein

canSAR Q9UBE8
Human Protein Atlas ENSG00000087095
IntAct Q9UBE8
Guide to Pharmacology 2125
Open Targets ENSG00000087095
PharmGKB PA134914500
Pharos Q9UBE8 (Tchem)
Reactome R-HSA-4086398 (Ca2+ pathway.)
UniProt B2RCX1 Q2PNI9 Q6P2A3 Q9UBE8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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