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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5347
Target Type SINGLE PROTEIN
Preferred Name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD | G6PD | Glucose-6-phosphate 1-dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glucose-6-phosphate 1-dehydrogenase SINGLE PROTEIN P11413

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160211
Ensembl ENSG00000160211
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004345 (glucose-6-phosphate dehydrogenase activity)
GO:0005515 (protein binding)
GO:0005536 (glucose binding)
GO:0016491 (oxidoreductase activity)
GO:0030246 (carbohydrate binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0050661 (NADP binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006098 (pentose-phosphate shunt)
GO:0006629 (lipid metabolic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006739 (NADP metabolic process)
GO:0006740 (NADPH regeneration)
GO:0006749 (glutathione metabolic process)
GO:0009051 (pentose-phosphate shunt, oxidative branch)
GO:0010734 (negative regulation of protein glutathionylation)
GO:0014070 (response to organic cyclic compound)
GO:0019322 (pentose biosynthetic process)
GO:0021762 (substantia nigra development)
GO:0032094 (response to food)
GO:0034599 (cellular response to oxidative stress)
GO:0043249 (erythrocyte maturation)
GO:0043523 (regulation of neuron apoptotic process)
GO:0045471 (response to ethanol)
GO:0046390 (ribose phosphate biosynthetic process)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Glucose-6-phosphate_dehydrogenase

Target Cross References - Protein

canSAR P11413
CGD Glucose-6-phosphate dehydrogenase deficiency
Human Protein Atlas ENSG00000160211
IntAct P11413
Open Targets ENSG00000160211
PharmGKB PA28469
Reactome R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-71336 (Pentose phosphate pathway (hexose monophosphate shunt).)
UniProt D3DWX9 P11413 Q16000 Q16765 Q8IU70 Q8IU88 Q8IUA6 Q96PQ2

Target Cross References - Domain

InterPro IPR001282 (G6P_DH.)
IPR016040 (NAD(P)-bd_dom.)
IPR019796 (G6P_DH_AS.)
IPR022674 (G6P_DH_NAD-bd.)
IPR022675 (G6P_DH_C.)
Pfam PF00479 (G6PD_N)
PF02781 (G6PD_C)

Target Cross References - Structure

PDBe 1QKI 2BH9 2BHL
CREDO 1QKI 2BH9 2BHL
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