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Target Report Card

Target Name and Classification

Target ID CHEMBL5332
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase 7
Synonyms BMK-1 | BMK1 | Big MAP kinase 1 | ERK-5 | ERK5 | Extracellular signal-regulated kinase 5 | MAP kinase 7 | MAPK 7 | MAPK7 | Mitogen-activated protein kinase 7 | PRKM7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase erk5

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 7 SINGLE PROTEIN Q13164

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166484
Ensembl ENSG00000166484
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016605 (PML body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0051019 (mitogen-activated protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019933 (cAMP-mediated signaling)
GO:0030154 (cell differentiation)
GO:0030821 (negative regulation of cAMP catabolic process)
GO:0034115 (negative regulation of heterotypic cell-cell adhesion)
GO:0036003 (positive regulation of transcription from RNA polymerase II promoter in response to stress)
GO:0043066 (negative regulation of apoptotic process)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045765 (regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050728 (negative regulation of inflammatory response)
GO:0051247 (positive regulation of protein metabolic process)
GO:0051344 (negative regulation of cyclic-nucleotide phosphodiesterase activity)
GO:0051534 (negative regulation of NFAT protein import into nucleus)
GO:0060761 (negative regulation of response to cytokine stimulus)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070377 (negative regulation of ERK5 cascade)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071499 (cellular response to laminar fluid shear stress)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia MAPK7

Target Cross References - Protein

canSAR Q13164
Human Protein Atlas ENSG00000166484
IntAct Q13164
Guide to Pharmacology 2093
Open Targets ENSG00000166484
PharmGKB PA30625
Pharos Q13164 (Tbio)
Reactome R-HSA-198753 (ERK/MAPK targets.)
R-HSA-198765 (Signalling to ERK5.)
R-HSA-202670 (ERKs are inactivated.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
R-HSA-8853659 (RET signaling.)
UniProt Q13164 Q16634 Q59F50 Q6QLU7 Q7L4P4 Q969G1 Q96G51

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ
CREDO 2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ
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