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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5331
Target Type SINGLE PROTEIN
Preferred Name Proto-oncogene tyrosine-protein kinase MER
Synonyms MER | MERTK | Proto-oncogene c-Mer | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase axl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Mer SINGLE PROTEIN Q12866

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137284 MER intracellular domain/EGFR extracellular domain chimera CHIMERIC PROTEIN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000153208
Ensembl ENSG00000153208
GO Cellular Component GO:0001750 (photoreceptor outer segment)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016028 (rhabdomere)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001779 (natural killer cell differentiation)
GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007283 (spermatogenesis)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030168 (platelet activation)
GO:0032940 (secretion by cell)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0043277 (apoptotic cell clearance)
GO:0043491 (protein kinase B signaling)
GO:0050766 (positive regulation of phagocytosis)
GO:0050900 (leukocyte migration)
GO:0051250 (negative regulation of lymphocyte activation)
GO:0060041 (retina development in camera-type eye)
GO:0060068 (vagina development)
GO:2000107 (negative regulation of leukocyte apoptotic process)
Wikipedia MERTK

Target Cross References - Protein

canSAR Q12866
CGD Retinitis pigmentosa 38
Human Protein Atlas ENSG00000153208
IntAct Q12866
Guide to Pharmacology 1837
Open Targets ENSG00000153208
PharmGKB PA30759
Pharos Q12866 (Tchem)
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
UniProt Q12866 Q9HBB4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003599 (Ig_sub.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00041 (fn3)
PF00047 (ig)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA
CREDO 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA
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