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Target Report Card

Target Name and Classification

Target ID CHEMBL5320
Target Type SINGLE PROTEIN
Preferred Name Myotonin-protein kinase
Synonyms DM-kinase | DM1 protein kinase | DM1PK | DMK | DMPK | DMPK | MDPK | MT-PK | Myotonic dystrophy protein kinase | Myotonin-protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase dmpk family > agc protein kinase gek subfamily

Target Components

Component Description Relationship Accession
Myotonin-protein kinase SINGLE PROTEIN Q09013

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104936
Ensembl ENSG00000104936
GO Cellular Component GO:0005634 (nucleus)
GO:0005640 (nuclear outer membrane)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0031307 (integral component of mitochondrial outer membrane)
GO:0031965 (nuclear membrane)
GO:0031966 (mitochondrial membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017020 (myosin phosphatase regulator activity)
GO:0031072 (heat shock protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002028 (regulation of sodium ion transport)
GO:0006468 (protein phosphorylation)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006998 (nuclear envelope organization)
GO:0008016 (regulation of heart contraction)
GO:0010657 (muscle cell apoptotic process)
GO:0010830 (regulation of myotube differentiation)
GO:0014722 (regulation of skeletal muscle contraction by calcium ion signaling)
GO:0014853 (regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0050790 (regulation of catalytic activity)
GO:0051823 (regulation of synapse structural plasticity)
GO:1903779 (regulation of cardiac conduction)
Wikipedia Myotonin-protein_kinase

Target Cross References - Protein

CGD Myotonic dystrophy 1
Human Protein Atlas ENSG00000104936
IntAct Q09013
Guide to Pharmacology 1505
Open Targets ENSG00000104936
PharmGKB PA27380
Pharos Q09013 (Tchem)
Reactome R-HSA-5578775 (Ion homeostasis.)
UniProt E5KR08 Q09013 Q16205 Q6P5Z6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014930 (Myotonic_dystrophy_kinase_coil.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF08826 (DMPK_coil)

Target Cross References - Structure

PDBe 1WT6 2VD5
CREDO 1WT6 2VD5
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