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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5319
Target Type SINGLE PROTEIN
Preferred Name Epithelial discoidin domain-containing receptor 1
Synonyms CAK | CD167 antigen-like family member A | CD_antigen=CD167a | Cell adhesion kinase | DDR1 | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain-containing receptor 1 | HGK2 | MCK-10 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase 3A | Protein-tyrosine kinase RTK-6 | RTK6 | TRK E | TRKE | Tyrosine kinase DDR | Tyrosine-protein kinase CAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase ddr family

Target Components

Component Description Relationship Accession
Epithelial discoidin domain-containing receptor 1 SINGLE PROTEIN Q08345

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137332 ENSG00000204580 ENSG00000215522 ENSG00000230456 ENSG00000234078
Ensembl ENSG00000137332 ENSG00000204580 ENSG00000215522 ENSG00000230456 ENSG00000234078
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0038062 (protein tyrosine kinase collagen receptor activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0001952 (regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007565 (female pregnancy)
GO:0007566 (embryo implantation)
GO:0007595 (lactation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010715 (regulation of extracellular matrix disassembly)
GO:0014909 (smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030198 (extracellular matrix organization)
GO:0038063 (collagen-activated tyrosine kinase receptor signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0043583 (ear development)
GO:0044319 (wound healing, spreading of cells)
GO:0046777 (protein autophosphorylation)
GO:0060444 (branching involved in mammary gland duct morphogenesis)
GO:0060749 (mammary gland alveolus development)
GO:0061302 (smooth muscle cell-matrix adhesion)
GO:0061564 (axon development)
GO:1990138 (neuron projection extension)
Wikipedia DDR1

Target Cross References - Protein

canSAR Q08345
Human Protein Atlas ENSG00000137332 ENSG00000204580 ENSG00000215522 ENSG00000230456 ENSG00000234078
IntAct Q08345
Guide to Pharmacology 1843
Open Targets ENSG00000137332 ENSG00000204580 ENSG00000215522 ENSG00000230456 ENSG00000234078
PharmGKB PA24348
Pharos Q08345 (Tchem)
Reactome R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
UniProt B5A975 B5A976 B7Z2K0 Q08345 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD35 Q9UD36 Q9UD37 Q9UD86 Q9UDL2

Target Cross References - Domain

InterPro IPR000421 (FA58C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR029553 (DDR1.)
Pfam PF00754 (F5_F8_type_C)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX
CREDO 3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX
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