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Target Report Card

Target Name and Classification

Target ID CHEMBL5318
Preferred Name Apoptosis regulator BAX
Synonyms Apoptosis regulator BAX | BAX | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > bcl-2 family

Target Components

Component Description Relationship Accession
Apoptosis regulator BAX SINGLE PROTEIN Q07812

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087088
Ensembl ENSG00000087088
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005757 (mitochondrial permeability transition pore complex)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO:0046930 (pore complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097136 (Bcl-2 family protein complex)
GO:0097144 (BAX complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0008289 (lipid binding)
GO:0015267 (channel activity)
GO:0031072 (heat shock protein binding)
GO:0032403 (protein complex binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051087 (chaperone binding)
GO:0051400 (BH domain binding)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0001541 (ovarian follicle development)
GO:0001764 (neuron migration)
GO:0001776 (leukocyte homeostasis)
GO:0001777 (T cell homeostatic proliferation)
GO:0001782 (B cell homeostasis)
GO:0001783 (B cell apoptotic process)
GO:0001822 (kidney development)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0001844 (protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:0001974 (blood vessel remodeling)
GO:0002262 (myeloid cell homeostasis)
GO:0002352 (B cell negative selection)
GO:0002358 (B cell homeostatic proliferation)
GO:0002904 (positive regulation of B cell apoptotic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006808 (regulation of nitrogen utilization)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007007 (inner mitochondrial membrane organization)
GO:0007008 (outer mitochondrial membrane organization)
GO:0007281 (germ cell development)
GO:0007283 (spermatogenesis)
GO:0007399 (nervous system development)
GO:0007420 (brain development)
GO:0007548 (sex differentiation)
GO:0007568 (aging)
GO:0008053 (mitochondrial fusion)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0008637 (apoptotic mitochondrial changes)
GO:0009566 (fertilization)
GO:0009611 (response to wounding)
GO:0009636 (response to toxic substance)
GO:0009651 (response to salt stress)
GO:0009791 (post-embryonic development)
GO:0010212 (response to ionizing radiation)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0010332 (response to gamma radiation)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0016032 (viral process)
GO:0021854 (hypothalamus development)
GO:0021987 (cerebral cortex development)
GO:0032091 (negative regulation of protein binding)
GO:0032461 (positive regulation of protein oligomerization)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0032471 (negative regulation of endoplasmic reticulum calcium ion concentration)
GO:0032976 (release of matrix enzymes from mitochondria)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0033599 (regulation of mammary gland epithelial cell proliferation)
GO:0034349 (glial cell apoptotic process)
GO:0034644 (cellular response to UV)
GO:0035108 (limb morphogenesis)
GO:0035234 (ectopic germ cell programmed cell death)
GO:0042220 (response to cocaine)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042493 (response to drug)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043496 (regulation of protein homodimerization activity)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0043653 (mitochondrial fragmentation involved in apoptotic process)
GO:0045136 (development of secondary sexual characteristics)
GO:0045333 (cellular respiration)
GO:0046666 (retinal cell programmed cell death)
GO:0046688 (response to copper ion)
GO:0048087 (positive regulation of developmental pigmentation)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0048515 (spermatid differentiation)
GO:0048597 (post-embryonic camera-type eye morphogenesis)
GO:0048678 (response to axon injury)
GO:0048872 (homeostasis of number of cells)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0051259 (protein oligomerization)
GO:0051260 (protein homooligomerization)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051402 (neuron apoptotic process)
GO:0051412 (response to corticosterone)
GO:0051726 (regulation of cell cycle)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0060011 (Sertoli cell proliferation)
GO:0060041 (retina development in camera-type eye)
GO:0060058 (positive regulation of apoptotic process involved in mammary gland involution)
GO:0060068 (vagina development)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070242 (thymocyte apoptotic process)
GO:0070584 (mitochondrion morphogenesis)
GO:0071310 (cellular response to organic substance)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)
GO:1902108 (regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1902110 (positive regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1902262 (apoptotic process involved in patterning of blood vessels)
GO:1902263 (apoptotic process involved in embryonic digit morphogenesis)
GO:1902445 (regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)
GO:1902512 (positive regulation of apoptotic DNA fragmentation)
GO:1903896 (positive regulation of IRE1-mediated unfolded protein response)
GO:1990117 (B cell receptor apoptotic signaling pathway)
GO:2001234 (negative regulation of apoptotic signaling pathway)
GO:2001241 (positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia Bcl-2-associated_X_protein

Target Cross References - Protein

canSAR Q07812
Human Protein Atlas ENSG00000087088
IntAct Q07812
Open Targets ENSG00000087088
PharmGKB PA25269
Reactome R-HSA-114294 (Activation, translocation and oligomerization of BAX.)
R-HSA-6803204 (TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt A8K4W1 P55269 Q07812 Q07814 Q07815 Q8WZ49 Q9NR76 Q9NYG7 Q9UCZ6 Q9UCZ7 Q9UQD6

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR026298 (Blc2_fam.)
IPR026304 (BAX.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2G5B 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII