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Target Report Card

Target Name and Classification

Target ID CHEMBL5318
Target Type SINGLE PROTEIN
Preferred Name Apoptosis regulator BAX
Synonyms Apoptosis regulator BAX | BAX | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > bcl-2 family

Target Components

Component Description Relationship Accession
Apoptosis regulator BAX SINGLE PROTEIN Q07812

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087088
Ensembl ENSG00000087088
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005757 (mitochondrial permeability transition pore complex)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO:0046930 (pore complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097136 (Bcl-2 family protein complex)
GO:0097144 (BAX complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0008289 (lipid binding)
GO:0015267 (channel activity)
GO:0031072 (heat shock protein binding)
GO:0032403 (protein complex binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051087 (chaperone binding)
GO:0051400 (BH domain binding)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0001541 (ovarian follicle development)
GO:0001764 (neuron migration)
GO:0001776 (leukocyte homeostasis)
GO:0001777 (T cell homeostatic proliferation)
GO:0001782 (B cell homeostasis)
GO:0001783 (B cell apoptotic process)
GO:0001822 (kidney development)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0001844 (protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:0001974 (blood vessel remodeling)
GO:0002262 (myeloid cell homeostasis)
GO:0002352 (B cell negative selection)
GO:0002358 (B cell homeostatic proliferation)
GO:0002904 (positive regulation of B cell apoptotic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006808 (regulation of nitrogen utilization)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007007 (inner mitochondrial membrane organization)
GO:0007008 (outer mitochondrial membrane organization)
GO:0007281 (germ cell development)
GO:0007283 (spermatogenesis)
GO:0007399 (nervous system development)
GO:0007420 (brain development)
GO:0007548 (sex differentiation)
GO:0007568 (aging)
GO:0008053 (mitochondrial fusion)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0008637 (apoptotic mitochondrial changes)
GO:0009566 (fertilization)
GO:0009611 (response to wounding)
GO:0009636 (response to toxic substance)
GO:0009651 (response to salt stress)
GO:0009791 (post-embryonic development)
GO:0010212 (response to ionizing radiation)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0010332 (response to gamma radiation)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0016032 (viral process)
GO:0021854 (hypothalamus development)
GO:0021987 (cerebral cortex development)
GO:0032091 (negative regulation of protein binding)
GO:0032461 (positive regulation of protein oligomerization)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0032471 (negative regulation of endoplasmic reticulum calcium ion concentration)
GO:0032976 (release of matrix enzymes from mitochondria)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0033599 (regulation of mammary gland epithelial cell proliferation)
GO:0034349 (glial cell apoptotic process)
GO:0034644 (cellular response to UV)
GO:0035108 (limb morphogenesis)
GO:0035234 (ectopic germ cell programmed cell death)
GO:0042220 (response to cocaine)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042493 (response to drug)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043496 (regulation of protein homodimerization activity)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0043653 (mitochondrial fragmentation involved in apoptotic process)
GO:0045136 (development of secondary sexual characteristics)
GO:0045333 (cellular respiration)
GO:0046666 (retinal cell programmed cell death)
GO:0046688 (response to copper ion)
GO:0048087 (positive regulation of developmental pigmentation)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0048515 (spermatid differentiation)
GO:0048597 (post-embryonic camera-type eye morphogenesis)
GO:0048678 (response to axon injury)
GO:0048872 (homeostasis of number of cells)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0051259 (protein oligomerization)
GO:0051260 (protein homooligomerization)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051402 (neuron apoptotic process)
GO:0051412 (response to corticosterone)
GO:0051726 (regulation of cell cycle)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0060011 (Sertoli cell proliferation)
GO:0060041 (retina development in camera-type eye)
GO:0060058 (positive regulation of apoptotic process involved in mammary gland involution)
GO:0060068 (vagina development)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070242 (thymocyte apoptotic process)
GO:0070584 (mitochondrion morphogenesis)
GO:0071310 (cellular response to organic substance)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)
GO:1902108 (regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1902110 (positive regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1902262 (apoptotic process involved in patterning of blood vessels)
GO:1902263 (apoptotic process involved in embryonic digit morphogenesis)
GO:1902445 (regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)
GO:1902512 (positive regulation of apoptotic DNA fragmentation)
GO:1903896 (positive regulation of IRE1-mediated unfolded protein response)
GO:1990117 (B cell receptor apoptotic signaling pathway)
GO:2001234 (negative regulation of apoptotic signaling pathway)
GO:2001241 (positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia Bcl-2-associated_X_protein

Target Cross References - Protein

canSAR Q07812
Human Protein Atlas ENSG00000087088
IntAct Q07812
Open Targets ENSG00000087088
PharmGKB PA25269
Reactome R-HSA-114294 (Activation, translocation and oligomerization of BAX.)
R-HSA-6803204 (TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt A8K4W1 P55269 Q07812 Q07814 Q07815 Q8WZ49 Q9NR76 Q9NYG7 Q9UCZ6 Q9UCZ7 Q9UQD6

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR026298 (Blc2_fam.)
IPR026304 (BAX.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2G5B 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII
CREDO 2G5B 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII
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