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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5315
Target Type SINGLE PROTEIN
Preferred Name Peroxiredoxin-1
Synonyms NKEF-A | Natural killer cell-enhancing factor A | PAG | PAGA | PAGB | PRDX1 | Peroxiredoxin-1 | Proliferation-associated gene protein | TDPX2 | Thioredoxin peroxidase 2 | Thioredoxin-dependent peroxide reductase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peroxiredoxin-1 SINGLE PROTEIN Q06830

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117450
Ensembl ENSG00000117450
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005913 (cell-cell adherens junction)
GO:0031012 (extracellular matrix)
GO:0042470 (melanosome)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0005515 (protein binding)
GO:0008379 (thioredoxin peroxidase activity)
GO:0016209 (antioxidant activity)
GO:0016491 (oxidoreductase activity)
GO:0042802 (identical protein binding)
GO:0044822 (poly(A) RNA binding)
GO:0051920 (peroxiredoxin activity)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0001501 (skeletal system development)
GO:0001895 (retina homeostasis)
GO:0006979 (response to oxidative stress)
GO:0008283 (cell proliferation)
GO:0019430 (removal of superoxide radicals)
GO:0032872 (regulation of stress-activated MAPK cascade)
GO:0034101 (erythrocyte homeostasis)
GO:0042267 (natural killer cell mediated cytotoxicity)
GO:0042345 (regulation of NF-kappaB import into nucleus)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0098609 (cell-cell adhesion)
Wikipedia Peroxiredoxin_1

Target Cross References - Protein

canSAR Q06830
Human Protein Atlas ENSG00000117450
IntAct Q06830
Open Targets ENSG00000117450
PharmGKB PA33722
Reactome R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
UniProt B5BU26 D3DPZ8 P35703 Q06830 Q2V576 Q5T154 Q5T155

Target Cross References - Domain

InterPro IPR000866 (AhpC/TSA.)
IPR012336 (Thioredoxin-like_fold.)
IPR019479 (Peroxiredoxin_C.)
IPR024706 (Peroxiredoxin_AhpC-typ.)
Pfam PF00578 (AhpC-TSA)
PF10417 (1-cysPrx_C)

Target Cross References - Structure

PDBe 2RII 3HY2 4XCS
CREDO 2RII 3HY2 4XCS
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