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Target Report Card

Target Name and Classification

Target ID CHEMBL5294
Preferred Name Forkhead box protein O1
Synonyms FKHR | FOXO1 | FOXO1A | Forkhead box protein O1 | Forkhead box protein O1A | Forkhead in rhabdomyosarcoma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Forkhead box protein O1 SINGLE PROTEIN Q12778

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150907
Ensembl ENSG00000150907
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0000989 (transcription factor activity, transcription factor binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001223 (transcription coactivator binding)
GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008134 (transcription factor binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001568 (blood vessel development)
GO:0001659 (temperature homeostasis)
GO:0001678 (cellular glucose homeostasis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0008286 (insulin receptor signaling pathway)
GO:0009267 (cellular response to starvation)
GO:0009653 (anatomical structure morphogenesis)
GO:0010508 (positive regulation of autophagy)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030154 (cell differentiation)
GO:0031018 (endocrine pancreas development)
GO:0032868 (response to insulin)
GO:0032869 (cellular response to insulin stimulus)
GO:0032873 (negative regulation of stress-activated MAPK cascade)
GO:0034599 (cellular response to oxidative stress)
GO:0035947 (regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter)
GO:0042127 (regulation of cell proliferation)
GO:0042593 (glucose homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043491 (protein kinase B signaling)
GO:0045444 (fat cell differentiation)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045722 (positive regulation of gluconeogenesis)
GO:0045732 (positive regulation of protein catabolic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0070166 (enamel mineralization)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070417 (cellular response to cold)
GO:0071455 (cellular response to hyperoxia)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071732 (cellular response to nitric oxide)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097009 (energy homeostasis)
GO:0097150 (neuronal stem cell population maintenance)
GO:1902617 (response to fluoride)
GO:1903243 (negative regulation of cardiac muscle hypertrophy in response to stress)
GO:2000177 (regulation of neural precursor cell proliferation)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia FOXO1

Target Cross References - Protein

canSAR Q12778
Human Protein Atlas ENSG00000150907
IntAct Q12778
Open Targets ENSG00000150907
PharmGKB PA28237
Reactome R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-211163 (AKT-mediated inactivation of FOXO1A.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt O43523 Q12778 Q5VYC7 Q6NSK6

Target Cross References - Domain

InterPro IPR001766 (Fork_head_dom.)
IPR030456 (TF_fork_head_CS_2.)
IPR032067 (FOXO-TAD.)
IPR032068 (FOXO_KIX-bd.)
IPR036388 (WH-like_DNA-bd_sf.)
IPR036390 (WH_DNA-bd_sf.)
Pfam PF00250 (Forkhead)
PF16675 (FOXO_KIX_bdg)
PF16676 (FOXO-TAD)

Target Cross References - Structure