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Target Report Card

Target Name and Classification

Target ID CHEMBL5293
Preferred Name Calcitonin gene-related peptide 1
Synonyms Alpha-type CGRP | CALC1 | CALCA | CGRP-I | Calcitonin gene-related peptide 1 | Calcitonin gene-related peptide I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Calcitonin gene-related peptide 1 SINGLE PROTEIN P06881

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832947 Calcitonin gene-related peptide PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110680
Ensembl ENSG00000110680
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005179 (hormone activity)
GO:0005515 (protein binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0001878 (response to yeast)
GO:0001935 (endothelial cell proliferation)
GO:0001944 (vasculature development)
GO:0001976 (neurological system process involved in regulation of systemic arterial blood pressure)
GO:0002031 (G-protein coupled receptor internalization)
GO:0006468 (protein phosphorylation)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0008217 (regulation of blood pressure)
GO:0010469 (regulation of receptor activity)
GO:0010523 (negative regulation of calcium ion transport into cytosol)
GO:0019731 (antibacterial humoral response)
GO:0019732 (antifungal humoral response)
GO:0030816 (positive regulation of cAMP metabolic process)
GO:0031623 (receptor internalization)
GO:0032730 (positive regulation of interleukin-1 alpha production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0043542 (endothelial cell migration)
GO:0045087 (innate immune response)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045776 (negative regulation of blood pressure)
GO:0045779 (negative regulation of bone resorption)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide)
GO:0097647 (amylin receptor signaling pathway)
GO:0097755 (positive regulation of blood vessel diameter)
GO:1990408 (calcitonin gene-related peptide receptor signaling pathway)
Wikipedia Calcitonin

Target Cross References - Protein

Human Protein Atlas ENSG00000110680
IntAct P06881
Open Targets ENSG00000110680
PharmGKB PA26029
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-419812 (Calcitonin-like ligand receptors.)
UniProt P06881 Q93048 Q9UCP0

Target Cross References - Domain

InterPro IPR001693 (Calcitonin_peptide-like.)
IPR015476 (Calcitonin_gene-rel_peptide.)
IPR018360 (Calcitonin_CS.)
IPR021116 (Calcitonin/adrenomedullin.)
IPR021117 (Calcitonin-like.)
Pfam PF00214 (Calc_CGRP_IAPP)