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Target Report Card

Target Name and Classification

Target ID CHEMBL5288
Target Type SINGLE PROTEIN
Preferred Name Retinoblastoma-associated protein
Synonyms RB1 | Rb | Retinoblastoma-associated protein | p105-Rb | pRb | pp110
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Retinoblastoma-associated protein SINGLE PROTEIN P06400

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139687
Ensembl ENSG00000139687
GO Cellular Component GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005819 (spindle)
GO:0008024 (cyclin/CDK positive transcription elongation factor complex)
GO:0016514 (SWI/SNF complex)
GO:0016605 (PML body)
GO:0035189 (Rb-E2F complex)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0019900 (kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0050681 (androgen receptor binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0000075 (cell cycle checkpoint)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007070 (negative regulation of transcription from RNA polymerase II promoter during mitosis)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007265 (Ras protein signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008285 (negative regulation of cell proliferation)
GO:0010629 (negative regulation of gene expression)
GO:0016032 (viral process)
GO:0016568 (chromatin modification)
GO:0030182 (neuron differentiation)
GO:0030521 (androgen receptor signaling pathway)
GO:0031134 (sister chromatid biorientation)
GO:0031175 (neuron projection development)
GO:0034088 (maintenance of mitotic sister chromatid cohesion)
GO:0034349 (glial cell apoptotic process)
GO:0035914 (skeletal muscle cell differentiation)
GO:0042551 (neuron maturation)
GO:0043353 (enucleate erythrocyte differentiation)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043550 (regulation of lipid kinase activity)
GO:0045445 (myoblast differentiation)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0045842 (positive regulation of mitotic metaphase/anaphase transition)
GO:0045879 (negative regulation of smoothened signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048565 (digestive tract development)
GO:0048667 (cell morphogenesis involved in neuron differentiation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0051146 (striated muscle cell differentiation)
GO:0051301 (cell division)
GO:0051402 (neuron apoptotic process)
GO:0051726 (regulation of cell cycle)
GO:0071459 (protein localization to chromosome, centromeric region)
GO:0071466 (cellular response to xenobiotic stimulus)
GO:0071922 (regulation of cohesin loading)
GO:0071930 (negative regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0090230 (regulation of centromere complex assembly)
GO:0097284 (hepatocyte apoptotic process)
GO:2000134 (negative regulation of G1/S transition of mitotic cell cycle)
GO:2000679 (positive regulation of transcription regulatory region DNA binding)
Wikipedia Retinoblastoma_protein

Target Cross References - Protein

canSAR P06400
CGD Retinoblastoma
Human Protein Atlas ENSG00000139687
IntAct P06400
Open Targets ENSG00000139687
PharmGKB PA295
Reactome R-HSA-113501 (Inhibition of replication initiation of damaged DNA by RB1/E2F1.)
R-HSA-2299718 (Condensation of Prophase Chromosomes.)
R-HSA-2559584 (Formation of Senescence-Associated Heterochromatin Foci (SAHF).)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-69200 (Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
UniProt A8K5E3 P06400 P78499 Q5VW46 Q8IZL4

Target Cross References - Domain

InterPro IPR002719 (RB_B.)
IPR002720 (RB_A.)
IPR013763 (Cyclin-like.)
IPR015030 (RB_C.)
IPR024599 (RB_N.)
IPR028309 (RB_fam.)
IPR033057 (RB1.)
Pfam PF01857 (RB_B)
PF01858 (RB_A)
PF08934 (Rb_C)
PF11934 (DUF3452)

Target Cross References - Structure

PDBe 1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL
CREDO 1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL
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