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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5287
Target Type SINGLE PROTEIN
Preferred Name Bile acid transporter
Synonyms Cell growth-inhibiting gene 29 protein | NTCP | Na(+)/bile acid cotransporter | Na(+)/taurocholate transport protein | SLC10A1 | Sodium/bile acid cotransporter | Sodium/taurocholate cotransporting polypeptide | Solute carrier family 10 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc10 family of sodium-bile acid co-transporters

Target Components

Component Description Relationship Accession
Sodium/bile acid cotransporter SINGLE PROTEIN Q14973

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100652
Ensembl ENSG00000100652
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0008508 (bile acid:sodium symporter activity)
GO Biological Process GO:0008206 (bile acid metabolic process)
GO:0015711 (organic anion transport)
Wikipedia SLC10A1

Target Cross References - Protein

canSAR Q14973
Human Protein Atlas ENSG00000100652
Guide to Pharmacology 959 (Sodium/bile acid and sulphated solute cotransporter 1)
PharmGKB PA317
Reactome REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt B9EGB6 Q14973 Q2TU29

Target Cross References - Domain

InterPro IPR002657 (BilAc/Na_symport.)
IPR004710 (Bil_ac_transpt.)
Pfam PF01758 (SBF)
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