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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5287
Target Type SINGLE PROTEIN
Preferred Name Bile acid transporter
Synonyms Cell growth-inhibiting gene 29 protein | NTCP | Na(+)/bile acid cotransporter | Na(+)/taurocholate transport protein | SLC10A1 | Sodium/bile acid cotransporter | Sodium/taurocholate cotransporting polypeptide | Solute carrier family 10 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc10 family of sodium-bile acid co-transporters

Target Components

Component Description Relationship Accession
Sodium/bile acid cotransporter SINGLE PROTEIN Q14973

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100652
Ensembl ENSG00000100652
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0008508 (bile acid:sodium symporter activity)
GO:0015125 (bile acid transmembrane transporter activity)
GO:0015293 (symporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0015721 (bile acid and bile salt transport)
GO:0016032 (viral process)
GO:0046718 (viral entry into host cell)
GO:0055085 (transmembrane transport)
Wikipedia SLC10A1

Target Cross References - Protein

canSAR Q14973
Human Protein Atlas ENSG00000100652
IntAct Q14973
Guide to Pharmacology 959
Open Targets ENSG00000100652
PharmGKB PA317
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
UniProt B9EGB6 Q14973 Q2TU29

Target Cross References - Domain

InterPro IPR002657 (BilAc:Na_symport/Acr3.)
IPR004710 (Bilac:Na_transpt.)
IPR030208 (SLC10A1.)
Pfam PF01758 (SBF)
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