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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5286
Target Type SINGLE PROTEIN
Preferred Name Collagen-binding protein 1
Synonyms 47 kDa heat shock protein | Arsenic-transactivated protein 3 | AsTP3 | CBP1 | CBP2 | Cell proliferation-inducing gene 14 protein | Collagen-binding protein | Colligin | HSP47 | Rheumatoid arthritis-related antigen RA-A47 | SERPINH1 | SERPINH2 | Serpin H1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Serpin H1 SINGLE PROTEIN P50454

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149257
Ensembl ENSG00000149257
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0005518 (collagen binding)
GO:0044822 (poly(A) RNA binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0003433 (chondrocyte development involved in endochondral bone morphogenesis)
GO:0006986 (response to unfolded protein)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0030199 (collagen fibril organization)
GO:0032964 (collagen biosynthetic process)
GO:0051604 (protein maturation)
Wikipedia Heat_shock_protein_47

Target Cross References - Protein

canSAR P50454
CGD Osteogenesis imperfecta, type X
Human Protein Atlas ENSG00000149257
IntAct P50454
Open Targets ENSG00000149257
PharmGKB PA35034
Reactome R-HSA-1650814 (Collagen biosynthesis and modifying enzymes.)
UniProt B3KVJ3 P29043 P50454 Q5XPB4 Q6NSJ6 Q8IY96 Q9NP88

Target Cross References - Domain

InterPro IPR000215 (Serpin_fam.)
IPR023795 (Serpin_CS.)
IPR023796 (Serpin_dom.)
Pfam PF00079 (Serpin)
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